Extranodal extension in oral cancer: A role for the nodal microenvironment?

• Published in: Journal of oral pathology & medicine Vol. 48; no. 10; pp. 863 - 870
• Main Authors: Pilborough, Alice E., Lambert, Daniel W., Khurram, Syed A.
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.11.2019
• Subjects: Biopsy; Carcinoma, Squamous Cell - pathology; Endothelial Cells; extracapsular spread; Extracellular matrix; extranodal extension; Extranodal Extension - pathology; Fibroblasts; Head & neck cancer; Head and neck; Humans; Inflammation; lymph node metastasis; Lymph Nodes; Lymphatic system; Metastases; Metastasis; Morbidity; Mouth Neoplasms - pathology; Oral cancer; Oral squamous cell carcinoma; Patients; Prognosis; Retrospective Studies; Squamous cell carcinoma; Surgery; Tumor Microenvironment; Tumors; tumour microenvironment; oral squamous cell carcinoma; tumour microenvironment; extracapsular spread; oral cancer; extranodal extension; lymph node metastasis

Oral squamous cell carcinoma (OSCC) is a significant cause of morbidity and mortality worldwide and accounts for the majority of head and neck cancers. Metastasis of primary tumours, primarily to cervical lymph nodes in the neck, is associated with worsening prognosis. Furthermore, the prognosis of...