Characterization of anticancer properties of 2,6-diisopropylphenol–docosahexaenoate and analogues in breast cancer cells

• Published in: Bioorganic & medicinal chemistry Vol. 18; no. 5; pp. 1866 - 1874
• Main Authors: Harvey, Kevin A., Xu, Zhidong, Whitley, Phillip, Jo Davisson, V., Siddiqui, Rafat A.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2010
• Subjects: 2,6-Diisopropylphenol; Animals; Antineoplastic Agents, Hormonal - chemical synthesis; Antineoplastic Agents, Hormonal - chemistry; Antineoplastic Agents, Hormonal - therapeutic use; Breast cancer; Breast Neoplasms - drug therapy; Cell Line, Tumor; Docosahexaenoic acid; Docosahexaenoic Acids - chemical synthesis; Docosahexaenoic Acids - chemistry; Docosahexaenoic Acids - therapeutic use; Estrogen Receptor alpha - metabolism; Female; Histone deacetylase; Histone Deacetylases - chemistry; Histone Deacetylases - metabolism; Humans; Lipid-drug conjugates; Mice; Propofol - chemistry; Receptor, ErbB-2 - metabolism; Lipid-drug conjugates; Histone deacetylase; Breast cancer; 2,6-Diisopropylphenol; Docosahexaenoic acid

The present study describes the characterization and evaluation of novel anticancer conjugates, 2,6-diisopropylphenol–docosahexaenoate (PP–DHA), and its analogues including 2,4-diisopropylphenol–docosahexaenoate (DIPP–DHA), 2-isopropylphenol–docosahexaenoate (IPP–DHA), 2-cyclohexanephenol-docosahexa...