The effect of preoperative radiotherapy on local control and prognosis in high-grade non-metastatic intramedullary osteosarcoma of the extremities
Introduction This study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated with neoadjuvant chemotherapy and limb-salvage surgery. Materials and methods Osteosarcoma patients who referred to our clinic from 1998 to 201...
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Published in | Archives of orthopaedic and trauma surgery Vol. 141; no. 7; pp. 1083 - 1089 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Berlin/Heidelberg
Springer Berlin Heidelberg
01.07.2021
Springer Nature B.V |
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Abstract | Introduction
This study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated with neoadjuvant chemotherapy and limb-salvage surgery.
Materials and methods
Osteosarcoma patients who referred to our clinic from 1998 to 2015 were investigated retrospectively. 141 patients with non-metastatic osteosarcoma of the limb who received neoadjuvant chemotherapy and underwent limb-sparing surgery with or without preoperative radiotherapy were included in the study. 73 patients had neoadjuvant chemotherapy only (CT group), while 68 patients had additional preoperative radiotherapy (CT + RT group). 5-year survival, disease-free survival, limb survival, local recurrence, metastasis, complication and necrosis rates were compared between the two groups.
Results
Overall 5-year survival, 5-year disease-free survival, 5-year limb survival rates were 68.5, 64.3, 65.7 for CT group and 72.1, 67.6, 64.7 for CT + RT group, respectively. Preoperative radiotherapy gave similar survival and disease-free survival rates. Limb survival, recurrence and metastasis rates were similar between the groups. The necrosis rate of the lesions was significantly higher in the CT + RT group compared to the CT group.
Conclusion
Preoperative radiotherapy can provide a higher necrosis rate and may allow the resection of unresectable lesions in the treatment of osteosarcoma. CT + RT provided similar 5-year survival despite the larger tumour size compared to CT group. Due to the higher wound complication rate (8.2% in CT, 23.5% in CT + RT group,
p
= 0.01), CT + RT should be restricted to the lesions with large size or close proximity to neurovascular structures.
Level of evidence
Level III; Therapeutic, Retrospective comparative study. |
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AbstractList | IntroductionThis study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated with neoadjuvant chemotherapy and limb-salvage surgery.Materials and methodsOsteosarcoma patients who referred to our clinic from 1998 to 2015 were investigated retrospectively. 141 patients with non-metastatic osteosarcoma of the limb who received neoadjuvant chemotherapy and underwent limb-sparing surgery with or without preoperative radiotherapy were included in the study. 73 patients had neoadjuvant chemotherapy only (CT group), while 68 patients had additional preoperative radiotherapy (CT + RT group). 5-year survival, disease-free survival, limb survival, local recurrence, metastasis, complication and necrosis rates were compared between the two groups.ResultsOverall 5-year survival, 5-year disease-free survival, 5-year limb survival rates were 68.5, 64.3, 65.7 for CT group and 72.1, 67.6, 64.7 for CT + RT group, respectively. Preoperative radiotherapy gave similar survival and disease-free survival rates. Limb survival, recurrence and metastasis rates were similar between the groups. The necrosis rate of the lesions was significantly higher in the CT + RT group compared to the CT group.ConclusionPreoperative radiotherapy can provide a higher necrosis rate and may allow the resection of unresectable lesions in the treatment of osteosarcoma. CT + RT provided similar 5-year survival despite the larger tumour size compared to CT group. Due to the higher wound complication rate (8.2% in CT, 23.5% in CT + RT group, p = 0.01), CT + RT should be restricted to the lesions with large size or close proximity to neurovascular structures.Level of evidenceLevel III; Therapeutic, Retrospective comparative study. Introduction This study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated with neoadjuvant chemotherapy and limb-salvage surgery. Materials and methods Osteosarcoma patients who referred to our clinic from 1998 to 2015 were investigated retrospectively. 141 patients with non-metastatic osteosarcoma of the limb who received neoadjuvant chemotherapy and underwent limb-sparing surgery with or without preoperative radiotherapy were included in the study. 73 patients had neoadjuvant chemotherapy only (CT group), while 68 patients had additional preoperative radiotherapy (CT + RT group). 5-year survival, disease-free survival, limb survival, local recurrence, metastasis, complication and necrosis rates were compared between the two groups. Results Overall 5-year survival, 5-year disease-free survival, 5-year limb survival rates were 68.5, 64.3, 65.7 for CT group and 72.1, 67.6, 64.7 for CT + RT group, respectively. Preoperative radiotherapy gave similar survival and disease-free survival rates. Limb survival, recurrence and metastasis rates were similar between the groups. The necrosis rate of the lesions was significantly higher in the CT + RT group compared to the CT group. Conclusion Preoperative radiotherapy can provide a higher necrosis rate and may allow the resection of unresectable lesions in the treatment of osteosarcoma. CT + RT provided similar 5-year survival despite the larger tumour size compared to CT group. Due to the higher wound complication rate (8.2% in CT, 23.5% in CT + RT group, p = 0.01), CT + RT should be restricted to the lesions with large size or close proximity to neurovascular structures. Level of evidence Level III; Therapeutic, Retrospective comparative study. |
Author | Karaismailoglu, Bedri Camurdan, Vedat Burkay Hız, Murat Ulutas, Suat Gorgun, Baris Oner Dincbas, Fazilet |
Author_xml | – sequence: 1 givenname: Murat surname: Hız fullname: Hız, Murat organization: Cerrahpasa Medical Faculty, Department of Orthopaedics and Traumatology, Istanbul University-Cerrahpasa – sequence: 2 givenname: Bedri orcidid: 0000-0002-4565-6383 surname: Karaismailoglu fullname: Karaismailoglu, Bedri email: bedrikio@hotmail.com organization: Cerrahpasa Medical Faculty, Department of Orthopaedics and Traumatology, Istanbul University-Cerrahpasa – sequence: 3 givenname: Suat surname: Ulutas fullname: Ulutas, Suat organization: Cerrahpasa Medical Faculty, Department of Orthopaedics and Traumatology, Istanbul University-Cerrahpasa – sequence: 4 givenname: Vedat Burkay surname: Camurdan fullname: Camurdan, Vedat Burkay organization: Cerrahpasa Medical Faculty, Department of Orthopaedics and Traumatology, Istanbul University-Cerrahpasa – sequence: 5 givenname: Baris surname: Gorgun fullname: Gorgun, Baris organization: Nisantasi Ortopedi Merkezi – sequence: 6 givenname: Fazilet surname: Oner Dincbas fullname: Oner Dincbas, Fazilet organization: Cerrahpasa Medical Faculty, Department of Radiation Oncology, Istanbul University-Cerrahpasa |
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Cites_doi | 10.1016/j.ejca.2016.12.016 10.1002/cncr.26037 10.1245/aso.2001.8.6.509 10.1007/s00402-019-03184-w 10.1002/cncr.10258 10.2106/JBJS.H.00449 10.1200/JCO.1994.12.2.423 10.1007/978-1-4419-0284-9_7 10.1007/s00402-019-03205-8 10.1002/1097-0142(19950501)75:9<2299::AID-CNCR2820750919>3.0.CO;2-Y 10.2307/3578662 10.1007/s00402-018-3059-x 10.5435/00124635-200908000-00005 10.1016/j.ijrobp.2004.11.006 10.1002/1097-0142(19840615)53:12<2579::AID-CNCR2820531202>3.0.CO;2-V 10.1002/1097-0142(197906)43:6<2163::AID-CNCR2820430602>3.0.CO;2-S 10.1002/cncr.27451 10.1200/JCO.1992.10.1.5 10.1007/s11999-015-4359-x 10.1016/j.ctrv.2006.05.005 10.1200/JCO.2003.01.142 10.1007/s00264-011-1209-7 10.1200/JCO.2002.20.3.776 10.1093/jnci/81.1.21 10.4065/78.2.147 |
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References | Shemesh, Pretell-Mazzini, Quartin (CR14) 2019; 139 Chambers, Mahoney (CR22) 1970; 36 Wanebo, Temple, Popp (CR8) 1995; 75 Stojadinovic, Jaques, Leung (CR12) 2001; 8 Ozaki, Flege, Matthias (CR18) 2003; 21 Larsen, Bruland, Hoff (CR15) 1994; 139 Bramwell (CR25) 1997; 24 Imran, Enders (CR26) 2009; 91 Machac, Tkachev, Solovyev (CR21) 2003; 78 Longhi, Errani, De Paolis (CR3) 2006; 32 Eilber, Morton, Eckardt (CR23) 1984; 53 Ozaki, Flege, Liljenqvist (CR17) 2002; 15 Davis, Bell, Goodwin (CR10) 1994; 12 Schwarz, Bruland, Cassoni (CR2) 2009; 152 Matsunobu, Imai, Kamada (CR20) 2012; 118 Bertrand, Cruz, Binitie (CR4) 2016; 474 Meyers, Heller, Healey (CR27) 1992; 10 Rosen, Marcova, Capparros (CR9) 1979; 43 Li, Ashana, Moretti, Lackman (CR6) 2011; 35 Taylor, Ivins, Unni (CR5) 1989; 81 Ciernik, Niemierko, Harmon (CR19) 2011; 117 Bielack, Kempf-Bielack, Delling (CR11) 2002; 20 Messerschmitt, Garcia, Abdul-Karim (CR1) 2009; 17 Cade (CR13) 1955; 11 Dinçbaş, Koca, Mandel (CR7) 2005; 62 Longhi, Bielack, Grimer (CR24) 2017; 74 Khan, Rankin, Todd (CR16) 2019; 139 Holzer, Huyer, Friesenbichler, Leithner (CR28) 2020 AM Davis (3494_CR10) 1994; 12 WF Taylor (3494_CR5) 1989; 81 A Matsunobu (3494_CR20) 2012; 118 FÖ Dinçbaş (3494_CR7) 2005; 62 A Longhi (3494_CR3) 2006; 32 SS Bielack (3494_CR11) 2002; 20 FR Eilber (3494_CR23) 1984; 53 RH Larsen (3494_CR15) 1994; 139 A Longhi (3494_CR24) 2017; 74 VHC Bramwell (3494_CR25) 1997; 24 TE Bertrand (3494_CR4) 2016; 474 HJ Wanebo (3494_CR8) 1995; 75 T Ozaki (3494_CR17) 2002; 15 LA Holzer (3494_CR28) 2020 S Cade (3494_CR13) 1955; 11 G Rosen (3494_CR9) 1979; 43 R Schwarz (3494_CR2) 2009; 152 A Stojadinovic (3494_CR12) 2001; 8 PA Meyers (3494_CR27) 1992; 10 X Li (3494_CR6) 2011; 35 T Ozaki (3494_CR18) 2003; 21 IF Ciernik (3494_CR19) 2011; 117 H Imran (3494_CR26) 2009; 91 SS Shemesh (3494_CR14) 2019; 139 M Khan (3494_CR16) 2019; 139 GN Machac (3494_CR21) 2003; 78 PJ Messerschmitt (3494_CR1) 2009; 17 RG Chambers (3494_CR22) 1970; 36 |
References_xml | – volume: 74 start-page: 9 year: 2017 end-page: 16 ident: CR24 article-title: Extraskeletal osteosarcoma: a European Musculoskeletal Oncology Society study on 266 patients publication-title: Eur J Cancer doi: 10.1016/j.ejca.2016.12.016 contributor: fullname: Grimer – volume: 117 start-page: 4522 year: 2011 end-page: 4530 ident: CR19 article-title: Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma publication-title: Cancer doi: 10.1002/cncr.26037 contributor: fullname: Harmon – volume: 8 start-page: 509 year: 2001 end-page: 518 ident: CR12 article-title: Amputation for recurrent soft tissue sarcoma of the extremity: indications and outcome publication-title: Ann Surg Oncol doi: 10.1245/aso.2001.8.6.509 contributor: fullname: Leung – volume: 139 start-page: 1659 year: 2019 end-page: 1666 ident: CR14 article-title: Surgical treatment of low-grade chondrosarcoma involving the appendicular skeleton: long-term functional and oncological outcomes publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-019-03184-w contributor: fullname: Quartin – volume: 15 start-page: 1069 year: 2002 end-page: 1077 ident: CR17 article-title: Osteosarcoma of the spine—experience of the Cooperative Osteosarcoma Study Group publication-title: Cancer doi: 10.1002/cncr.10258 contributor: fullname: Liljenqvist – volume: 91 start-page: 604 year: 2009 end-page: 612 ident: CR26 article-title: Effect of time to resumption of chemotherapy after definitive surgery on prognosis for non-metastatic osteosarcoma publication-title: J Bone Jt Surg Ser A doi: 10.2106/JBJS.H.00449 contributor: fullname: Enders – volume: 12 start-page: 423 year: 1994 end-page: 431 ident: CR10 article-title: Prognostic factors in osteosarcoma: a critical review publication-title: J Clin Oncol doi: 10.1200/JCO.1994.12.2.423 contributor: fullname: Goodwin – volume: 152 start-page: 147 year: 2009 end-page: 164 ident: CR2 article-title: The Role of radiotherapy in oseosarcoma publication-title: Cancer Treat Res doi: 10.1007/978-1-4419-0284-9_7 contributor: fullname: Cassoni – year: 2020 ident: CR28 article-title: Body image, self-esteem, and quality of life in patients with primary malignant bone tumors publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-019-03205-8 contributor: fullname: Leithner – volume: 75 start-page: 2299 year: 1995 end-page: 2306 ident: CR8 article-title: Preoperative regional therapy for extremity sarcoma, a tricenter update publication-title: Cancer doi: 10.1002/1097-0142(19950501)75:9<2299::AID-CNCR2820750919>3.0.CO;2-Y contributor: fullname: Popp – volume: 139 start-page: 178 year: 1994 end-page: 184 ident: CR15 article-title: Inactivation of human osteosarcoma cells in vitro by 211At-TP-3 monoclonal antibody; comparison with Astatine-21-labelled bovine serum albumon, free Astatine-211 and external-beam X rays publication-title: Rad Res doi: 10.2307/3578662 contributor: fullname: Hoff – volume: 11 start-page: 79 year: 1955 end-page: 111 ident: CR13 article-title: Osteogenic sarcoma: a study based on 133 patients publication-title: J R Coll Surg Edinb contributor: fullname: Cade – volume: 139 start-page: 443 year: 2019 end-page: 449 ident: CR16 article-title: Surgical excision and not chemotherapy is the most powerful modality in treating synovial sarcoma: the UK’s North East experience publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-018-3059-x contributor: fullname: Todd – volume: 17 start-page: 515 year: 2009 end-page: 527 ident: CR1 article-title: Osteosarcoma publication-title: J Am Acad Orthop Surg doi: 10.5435/00124635-200908000-00005 contributor: fullname: Abdul-Karim – volume: 62 start-page: 820 year: 2005 end-page: 828 ident: CR7 article-title: The role of preoperative radiotherapy in nonmetastatic high-grade osteosarcoma of the extremities for limb-sparing surgery publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2004.11.006 contributor: fullname: Mandel – volume: 53 start-page: 2579 year: 1984 end-page: 2584 ident: CR23 article-title: Limb salvage for skeletal and soft tissue sarcomas: multidisciplinary preoperative therapy publication-title: Cancer doi: 10.1002/1097-0142(19840615)53:12<2579::AID-CNCR2820531202>3.0.CO;2-V contributor: fullname: Eckardt – volume: 43 start-page: 2163 year: 1979 end-page: 2177 ident: CR9 article-title: Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery publication-title: Cancer doi: 10.1002/1097-0142(197906)43:6<2163::AID-CNCR2820430602>3.0.CO;2-S contributor: fullname: Capparros – volume: 118 start-page: 4555 year: 2012 end-page: 4563 ident: CR20 article-title: Impact of carbon ion radiotherapy for unresectable osteosarcoma of the trunk publication-title: Cancer doi: 10.1002/cncr.27451 contributor: fullname: Kamada – volume: 10 start-page: 5 year: 1992 end-page: 15 ident: CR27 article-title: Chemotherapy for nonmetastatic osteogenic sarcoma: The memorial sloan-kettering experience publication-title: J Clin Oncol doi: 10.1200/JCO.1992.10.1.5 contributor: fullname: Healey – volume: 474 start-page: 677 year: 2016 end-page: 683 ident: CR4 article-title: Do surgical margins affect local recurrence and survival in extremity, nonmetastatic, high-grade osteosarcoma? publication-title: Clin Orthop Relat Res doi: 10.1007/s11999-015-4359-x contributor: fullname: Binitie – volume: 36 start-page: 463 year: 1970 end-page: 471 ident: CR22 article-title: Osteogenic sarcoma of the mandible, current management publication-title: Am Surg contributor: fullname: Mahoney – volume: 32 start-page: 423 year: 2006 end-page: 436 ident: CR3 article-title: Primary bone osteosarcoma in the pediatric age: state of the art publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2006.05.005 contributor: fullname: De Paolis – volume: 21 start-page: 334 year: 2003 end-page: 341 ident: CR18 article-title: Osteosarcoma of the pelvis: Experience of the Cooperative Osteosarcoma Study Group publication-title: J Clin Oncol doi: 10.1200/JCO.2003.01.142 contributor: fullname: Matthias – volume: 24 start-page: 561 year: 1997 end-page: 571 ident: CR25 article-title: The role of chemotherapy in the management of non-metastatic operable extremity osteosarcoma publication-title: Semin Oncol contributor: fullname: Bramwell – volume: 35 start-page: 1847 year: 2011 end-page: 1853 ident: CR6 article-title: The relation of tumour necrosis and survival in patients with osteosarcoma publication-title: Int Orthop doi: 10.1007/s00264-011-1209-7 contributor: fullname: Lackman – volume: 20 start-page: 776 year: 2002 end-page: 790 ident: CR11 article-title: Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols publication-title: J Clin Oncol doi: 10.1200/JCO.2002.20.3.776 contributor: fullname: Delling – volume: 81 start-page: 21 year: 1989 end-page: 30 ident: CR5 article-title: Prognostic variables in osteosarcoma: a multi-institutional study publication-title: J Natl Cancer Inst doi: 10.1093/jnci/81.1.21 contributor: fullname: Unni – volume: 78 start-page: 147 year: 2003 end-page: 155 ident: CR21 article-title: Neoadjuvant chemotherapy and local radiotherapy for high-grade osteosarcoma of the extremities publication-title: Mayo Clin Proc doi: 10.4065/78.2.147 contributor: fullname: Solovyev – volume: 74 start-page: 9 year: 2017 ident: 3494_CR24 publication-title: Eur J Cancer doi: 10.1016/j.ejca.2016.12.016 contributor: fullname: A Longhi – volume: 139 start-page: 178 year: 1994 ident: 3494_CR15 publication-title: Rad Res doi: 10.2307/3578662 contributor: fullname: RH Larsen – volume: 152 start-page: 147 year: 2009 ident: 3494_CR2 publication-title: Cancer Treat Res doi: 10.1007/978-1-4419-0284-9_7 contributor: fullname: R Schwarz – volume: 62 start-page: 820 year: 2005 ident: 3494_CR7 publication-title: Int J Radiat Oncol Biol Phys doi: 10.1016/j.ijrobp.2004.11.006 contributor: fullname: FÖ Dinçbaş – volume: 35 start-page: 1847 year: 2011 ident: 3494_CR6 publication-title: Int Orthop doi: 10.1007/s00264-011-1209-7 contributor: fullname: X Li – volume: 91 start-page: 604 year: 2009 ident: 3494_CR26 publication-title: J Bone Jt Surg Ser A doi: 10.2106/JBJS.H.00449 contributor: fullname: H Imran – volume: 474 start-page: 677 year: 2016 ident: 3494_CR4 publication-title: Clin Orthop Relat Res doi: 10.1007/s11999-015-4359-x contributor: fullname: TE Bertrand – volume: 11 start-page: 79 year: 1955 ident: 3494_CR13 publication-title: J R Coll Surg Edinb contributor: fullname: S Cade – volume: 53 start-page: 2579 year: 1984 ident: 3494_CR23 publication-title: Cancer doi: 10.1002/1097-0142(19840615)53:12<2579::AID-CNCR2820531202>3.0.CO;2-V contributor: fullname: FR Eilber – volume: 139 start-page: 1659 year: 2019 ident: 3494_CR14 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-019-03184-w contributor: fullname: SS Shemesh – volume: 81 start-page: 21 year: 1989 ident: 3494_CR5 publication-title: J Natl Cancer Inst doi: 10.1093/jnci/81.1.21 contributor: fullname: WF Taylor – volume: 8 start-page: 509 year: 2001 ident: 3494_CR12 publication-title: Ann Surg Oncol doi: 10.1245/aso.2001.8.6.509 contributor: fullname: A Stojadinovic – volume: 139 start-page: 443 year: 2019 ident: 3494_CR16 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-018-3059-x contributor: fullname: M Khan – volume: 117 start-page: 4522 year: 2011 ident: 3494_CR19 publication-title: Cancer doi: 10.1002/cncr.26037 contributor: fullname: IF Ciernik – volume: 15 start-page: 1069 year: 2002 ident: 3494_CR17 publication-title: Cancer doi: 10.1002/cncr.10258 contributor: fullname: T Ozaki – volume: 12 start-page: 423 year: 1994 ident: 3494_CR10 publication-title: J Clin Oncol doi: 10.1200/JCO.1994.12.2.423 contributor: fullname: AM Davis – volume: 78 start-page: 147 year: 2003 ident: 3494_CR21 publication-title: Mayo Clin Proc doi: 10.4065/78.2.147 contributor: fullname: GN Machac – volume: 36 start-page: 463 year: 1970 ident: 3494_CR22 publication-title: Am Surg contributor: fullname: RG Chambers – volume: 17 start-page: 515 year: 2009 ident: 3494_CR1 publication-title: J Am Acad Orthop Surg doi: 10.5435/00124635-200908000-00005 contributor: fullname: PJ Messerschmitt – volume: 10 start-page: 5 year: 1992 ident: 3494_CR27 publication-title: J Clin Oncol doi: 10.1200/JCO.1992.10.1.5 contributor: fullname: PA Meyers – volume: 21 start-page: 334 year: 2003 ident: 3494_CR18 publication-title: J Clin Oncol doi: 10.1200/JCO.2003.01.142 contributor: fullname: T Ozaki – volume: 24 start-page: 561 year: 1997 ident: 3494_CR25 publication-title: Semin Oncol contributor: fullname: VHC Bramwell – volume: 32 start-page: 423 year: 2006 ident: 3494_CR3 publication-title: Cancer Treat Rev doi: 10.1016/j.ctrv.2006.05.005 contributor: fullname: A Longhi – volume: 20 start-page: 776 year: 2002 ident: 3494_CR11 publication-title: J Clin Oncol doi: 10.1200/JCO.2002.20.3.776 contributor: fullname: SS Bielack – volume: 43 start-page: 2163 year: 1979 ident: 3494_CR9 publication-title: Cancer doi: 10.1002/1097-0142(197906)43:6<2163::AID-CNCR2820430602>3.0.CO;2-S contributor: fullname: G Rosen – volume: 118 start-page: 4555 year: 2012 ident: 3494_CR20 publication-title: Cancer doi: 10.1002/cncr.27451 contributor: fullname: A Matsunobu – volume: 75 start-page: 2299 year: 1995 ident: 3494_CR8 publication-title: Cancer doi: 10.1002/1097-0142(19950501)75:9<2299::AID-CNCR2820750919>3.0.CO;2-Y contributor: fullname: HJ Wanebo – year: 2020 ident: 3494_CR28 publication-title: Arch Orthop Trauma Surg doi: 10.1007/s00402-019-03205-8 contributor: fullname: LA Holzer |
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This study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated... IntroductionThis study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated... INTRODUCTIONThis study aimed to analyse the effect of preoperative radiotherapy on survival, recurrence and necrosis rates in osteosarcoma patients treated... |
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SubjectTerms | Bone cancer Chemotherapy Medical prognosis Medicine Medicine & Public Health Metastasis Orthopaedic Surgery Orthopedics Radiation therapy Sarcoma |
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Title | The effect of preoperative radiotherapy on local control and prognosis in high-grade non-metastatic intramedullary osteosarcoma of the extremities |
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