Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

• Published in: Nature medicine Vol. 2; no. 11; pp. 1254 - 1258
• Main Authors: Scrocchi, L.A., Brown, T.J., Maclusky, N., Brubaker, P.L., Auerbach, A.B., Joyner, A.L., Drucker, D.J.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.11.1996
• Subjects: Animals; Biomedical and Life Sciences; Biomedicine; Blood Glucose - analysis; Cancer Research; Female; Gene Deletion; Glucagon - pharmacology; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glucose - metabolism; Glucose - pharmacology; Glucose Intolerance; Infectious Diseases; Insulin - blood; Male; Metabolic Diseases; Mice; Molecular Medicine; Neurosciences; Peptide Fragments - pharmacology; Protein Precursors - pharmacology; Rats; Receptors, Glucagon - genetics; Receptors, Glucagon - metabolism

Glucagon–like peptide 1 (GLP1) is postulated to regulate blood glucose and satiety, but the biological importance of GLP1 as an incretin and neuropeptide remains controversial. The regulation of nutrient–induced insulin secretion is dependent on the secretion of incretins, gut–derived peptides that...