Infection and the Risk of Spontaneous Cervical Artery Dissection A Case-Control Study

Background and Purpose— Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study. Methods— Forty-seven patient...

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Published inStroke (1970) Vol. 34; no. 7; p. e79
Main Authors Guillon, Benoît, Berthet, Karine, Benslamia, Lamia, Bertrand, Marion, Bousser, Marie-Germaine, Tzourio, Christophe
Format Journal Article
LanguageEnglish
Published United States 01.07.2003
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ISSN0039-2499
1524-4628
1524-4628
DOI10.1161/01.STR.0000078309.56307.5C

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Abstract Background and Purpose— Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study. Methods— Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event. Results— Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P =0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection. Conclusions— Recent infection is a risk factor and could be a trigger for SCAD.
AbstractList Background and Purpose— Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study. Methods— Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event. Results— Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P =0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection. Conclusions— Recent infection is a risk factor and could be a trigger for SCAD.
Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study. Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event. Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection. Recent infection is a risk factor and could be a trigger for SCAD.
Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study.BACKGROUND AND PURPOSESeveral constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored the association between recent infection and SCAD in an hospital-based case-control study.Forty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event.METHODSForty-seven patients with SCAD and 52 with ischemic stroke from another cause were prospectively and consecutively recruited by 2 neurology departments. A specially designed questionnaire was used to assess the history of an acute infection that could have occurred within a month before the vascular event.Acute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection.RESULTSAcute infection was more frequent in patients with SCAD (31.9%) than in control subjects (13.5%) (crude odds ratio, 3.0; 95% confidence interval, 1.1 to 8.2; P=0.032). This association was stronger in patients with multiple (odds ratio, 6.4) than single artery (odds ratio, 2.1) dissection.Recent infection is a risk factor and could be a trigger for SCAD.CONCLUSIONSRecent infection is a risk factor and could be a trigger for SCAD.
Author Bertrand, Marion
Tzourio, Christophe
Berthet, Karine
Benslamia, Lamia
Bousser, Marie-Germaine
Guillon, Benoît
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  surname: Guillon
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  organization: From Department of Neurology, Nantes Hospital, Nantes (B.G.); Department of Neurology, Lariboisière Hospital, Paris (C.T., K.B., L.M., M.-G.B.); and INSERM Unit 360, Salpêtrière Hospital, Paris (C.T., M.B.), France
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  givenname: Lamia
  surname: Benslamia
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  organization: From Department of Neurology, Nantes Hospital, Nantes (B.G.); Department of Neurology, Lariboisière Hospital, Paris (C.T., K.B., L.M., M.-G.B.); and INSERM Unit 360, Salpêtrière Hospital, Paris (C.T., M.B.), France
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  givenname: Marion
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  organization: From Department of Neurology, Nantes Hospital, Nantes (B.G.); Department of Neurology, Lariboisière Hospital, Paris (C.T., K.B., L.M., M.-G.B.); and INSERM Unit 360, Salpêtrière Hospital, Paris (C.T., M.B.), France
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  givenname: Marie-Germaine
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  organization: From Department of Neurology, Nantes Hospital, Nantes (B.G.); Department of Neurology, Lariboisière Hospital, Paris (C.T., K.B., L.M., M.-G.B.); and INSERM Unit 360, Salpêtrière Hospital, Paris (C.T., M.B.), France
– sequence: 6
  givenname: Christophe
  surname: Tzourio
  fullname: Tzourio, Christophe
  organization: From Department of Neurology, Nantes Hospital, Nantes (B.G.); Department of Neurology, Lariboisière Hospital, Paris (C.T., K.B., L.M., M.-G.B.); and INSERM Unit 360, Salpêtrière Hospital, Paris (C.T., M.B.), France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/12805497$$D View this record in MEDLINE/PubMed
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Snippet Background and Purpose— Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection...
Several constitutional and environmental risk factors may be involved in the occurrence of spontaneous cervical artery dissection (SCAD). This work explored...
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StartPage e79
SubjectTerms Acute Disease
Adult
Brain Ischemia - epidemiology
Carotid Artery, Internal, Dissection - epidemiology
Case-Control Studies
Causality
Comorbidity
Female
France - epidemiology
Humans
Infection - epidemiology
Male
Middle Aged
Neck - blood supply
Odds Ratio
Risk Assessment
Risk Factors
Stroke - epidemiology
Vertebral Artery Dissection - epidemiology
Subtitle A Case-Control Study
Title Infection and the Risk of Spontaneous Cervical Artery Dissection
URI https://www.ncbi.nlm.nih.gov/pubmed/12805497
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Volume 34
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