Large-Scale Survey of Gut Microbiota Associated With MHE Via 16S rRNA-Based Pyrosequencing

• Published in: The American journal of gastroenterology Vol. 108; no. 10; pp. 1601 - 1611
• Main Authors: Zhang, Zhigang, Zhai, Huiqin, Geng, Jiawei, Yu, Rui, Ren, Haiqing, Fan, Hong, Shi, Peng
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.10.2013
• Subjects: Abundance; Adult; Aged; Case-Control Studies; Feces - microbiology; Female; Gastroenterology; Gastrointestinal Tract - microbiology; Hepatic Encephalopathy - etiology; Hepatic Encephalopathy - microbiology; Humans; Liver Cirrhosis - complications; Liver Cirrhosis - microbiology; Male; Metagenome - genetics; Middle Aged; RNA, Ribosomal, 16S - analysis; Severity of Illness Index; Streptococcaceae; Streptococcaceae - genetics; Veillonellaceae - genetics

Elucidating the minimal hepatic encephalopathy (MHE)-associated gut microbiome may help in predicting and lowering the high risk for MHE in patients with cirrhosis. Twenty-six MHE patients were recruited and screened from among those with liver cirrhosis without overt hepatic encephalopathy as defin...