Beta-adrenergic stimulation of aldosterone production by rat adrenal capsular explants

• Published in: Endocrinology (Philadelphia) Vol. 117; no. 3; p. 1189
• Main Authors: Pratt, J H, Turner, D A, McAteer, J A, Henry, D P
• Format: Journal Article
• Language: English
• Published: United States 01.09.1985
• Subjects: 1-Methyl-3-isobutylxanthine - pharmacology; Adrenal Medulla - metabolism; Aldosterone - biosynthesis; Animals; Clonidine - pharmacology; Dopamine - pharmacology; Epinephrine - pharmacology; Female; Isoproterenol - pharmacology; Norepinephrine - pharmacology; Phenylephrine - pharmacology; Propranolol - pharmacology; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta - metabolism

Adrenal glomerulosa was examined for the presence of an adrenergic influence on aldosterone production. Cultured rat adrenal capsular explants were transferred to a perifusion system where the effect of exposure to catecholamines on aldosterone production was assessed. At 10(-6) M, isoproterenol gre...