Mechanisms Underlying Host Range Variation in Flavivirus: From Empirical Knowledge to Predictive Models

• Published in: Journal of molecular evolution Vol. 89; no. 6; pp. 329 - 340
• Main Authors: Halabi, Keren, Mayrose, Itay
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Aquatic insects; Biomedical and Life Sciences; Cell Biology; Dengue fever; Disease transmission; Evolutionary Biology; Flavivirus; Host range; Insects; Life Sciences; Microbiology; Morbidity; Mosquitoes; Phylogeny; Plant Genetics and Genomics; Plant Sciences; Prediction models; Predictive control; Review; Ticks; Vector-borne diseases; Vectors (Biology); Vertebrates; Viruses; Yellow fever; Phylogeny; Host-shifts; Machine learning; Genome composition

Preventing and controlling epidemics caused by vector-borne viruses are particularly challenging due to their diverse pool of hosts and highly adaptive nature. Many vector-borne viruses belong to the Flavivirus genus, whose members vary greatly in host range and specificity. Members of the Flaviviru...