The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling

• Published in: Pharmacology, biochemistry and behavior Vol. 101; no. 1; pp. 35 - 40
• Main Authors: Bradley, Stefania Risso, Uslaner, Jason M., Flick, Rose B., Lee, Ariel, Groover, Kristina M., Hutson, Peter H.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2012
• Subjects: AMPA receptors; Animals; Antidepressants; Antidepressive Agents - pharmacology; Benzhydryl Compounds - pharmacology; CHO Cells; Conditioning, Operant - drug effects; Cricetinae; Cricetulus; Cyclic AMP - metabolism; Glutamic Acid - physiology; Hindlimb Suspension - physiology; Hippocampus - drug effects; Hippocampus - metabolism; Immunohistochemistry; Male; Metabotropic glutamate receptor 7; Mice; Mice, Inbred C57BL; NR1; NR2b subunits; Phosphorylation; Phosphorylation of GluR1; Quinoxalines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, AMPA - agonists; Receptors, AMPA - metabolism; Receptors, Metabotropic Glutamate - agonists; Receptors, N-Methyl-D-Aspartate - metabolism; Reinforcement Schedule; Signal Transduction - drug effects; mGluR7; AMPA; NR2b subunits; AMN082; Antidepressants; NMDA; Phosphorylation of GluR1; AMPA receptors; NR1; NBQX; Metabotropic glutamate receptor 7

Currently prescribed antidepressants affect the reuptake and/or metabolism of biogenic amines. Unfortunately for patients, these treatments require several weeks to produce significant symptom remission. However, recently it has been found that ketamine, a dissociative anesthetic agent that noncompe...