The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling - Bradley, Stefania Risso; Uslaner, Jason M.; Flick, Rose B.; Lee, Ariel; Groover, Kristina M.; Hutson, Peter H. (Pharmacology, biochemistry and behavior, 2012)
Keywords: AMPA receptors; Animals; Antidepressants; Antidepressive Agents - pharmacology; Benzhydryl Compounds - pharmacology; CHO Cells; Conditioning, Operant - drug effects; Cricetinae; Cricetulus; Cyclic AMP - metabolism; Glutamic Acid - physiology; Hindlimb Suspension - physiology; Hippocampus - drug effects; Hippocampus - metabolism; Immunohistochemistry; Male; Metabotropic glutamate receptor 7; Mice; Mice, Inbred C57BL; NR1; NR2b subunits; Phosphorylation; Phosphorylation of GluR1; Quinoxalines - pharmacology; Rats; Rats, Sprague-Dawley; Receptors, AMPA - agonists; Receptors, AMPA - metabolism; Receptors, Metabotropic Glutamate - agonists; Receptors, N-Methyl-D-Aspartate - metabolism; Reinforcement Schedule; Signal Transduction - drug effects; mGluR7; AMPA; NR2b subunits; AMN082; Antidepressants; NMDA; Phosphorylation of GluR1; AMPA receptors; NR1; NBQX; Metabotropic glutamate receptor 7