A facilely synthesized glutathione-functionalized silver nanoparticle-grafted covalent organic framework for rapid and highly efficient enrichment of N-linked glycopeptides

• Published in: Nanoscale Vol. 11; no. 12; pp. 5526 - 5534
• Main Authors: Ma, Yu-Fang, Wang, Li-Juan, Zhou, Ying-Lin, Zhang, Xin-Xiang
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 28.03.2019
• Subjects: Antibiotics; Binding sites; Biological properties; Dispersion; Energy transmission; Enrichment; Fourier transforms; Glutathione; Glycopeptides; Mass spectrometry; Microscopy; Nanoparticles; NMR; Nuclear magnetic resonance; Porous materials; Scanning electron microscopy; Selectivity; Sensitivity analysis; Serum albumin; Silver; Substrates; Synthesis; Transmission electron microscopy; X-ray diffraction

The development of facilely synthetic materials for highly efficient enrichment of N-linked glycopeptides is essential in glycoproteome analysis. In this work, by utilizing the self-assembling of glutathione (GSH) on silver nanoparticles (Ag NPs), and the formation and dispersion of Ag NPs on a robu...