Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologica...

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Published inColloid and interface science communications Vol. 35; p. 100244
Main Authors Prasher, Parteek, Sharma, Mousmee, Mudila, Harish, Gupta, Gaurav, Sharma, Abhishek Kumar, Kumar, Deepak, Bakshi, Hamid A., Negi, Poonam, Kapoor, Deepak N., Chellappan, Dinesh Kumar, Tambuwala, Murtaza M., Dua, Kamal
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.03.2020
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Abstract From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologically benevolent moieties that enhance the bio-acceptability of silver-based nanosystems, and supplementary functionalities for further extension of their unique applications. The clinical importance of AgNPs was established long ago, but their clinical utilization has been explored only recently with the phenomenon of bio-conjugation. The biomolecule-conjugated AgNPs present operable solutions for tedious clinical complications of the present era, such as multidrug resistance, designing of pharmaceuticals with improved bioavailability, superior drug delivery vehicles and in situ bio imaging of important metabolites that utilize the biomolecule-anchored surface engineered AgNPs. This review epigrammatically discusses some interesting clinical applications of surface conjugated AgNPs with biomolecules such as peptides, nucleic acids, amino acids and antibodies in the current nanopharmaceutical paradigm. [Display omitted] •This review article highlights:•Surface functionalization of AgNPs prior to bioconjugation.•Bio-conjugation strategies for AgNPs.•Various clinical applications of bio-conjugated AgNPs.
AbstractList From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologically benevolent moieties that enhance the bio-acceptability of silver-based nanosystems, and supplementary functionalities for further extension of their unique applications. The clinical importance of AgNPs was established long ago, but their clinical utilization has been explored only recently with the phenomenon of bio-conjugation. The biomolecule-conjugated AgNPs present operable solutions for tedious clinical complications of the present era, such as multidrug resistance, designing of pharmaceuticals with improved bioavailability, superior drug delivery vehicles and in situ bio imaging of important metabolites that utilize the biomolecule-anchored surface engineered AgNPs. This review epigrammatically discusses some interesting clinical applications of surface conjugated AgNPs with biomolecules such as peptides, nucleic acids, amino acids and antibodies in the current nanopharmaceutical paradigm. [Display omitted] •This review article highlights:•Surface functionalization of AgNPs prior to bioconjugation.•Bio-conjugation strategies for AgNPs.•Various clinical applications of bio-conjugated AgNPs.
ArticleNumber 100244
Author Bakshi, Hamid A.
Sharma, Mousmee
Gupta, Gaurav
Sharma, Abhishek Kumar
Kapoor, Deepak N.
Dua, Kamal
Tambuwala, Murtaza M.
Kumar, Deepak
Prasher, Parteek
Chellappan, Dinesh Kumar
Mudila, Harish
Negi, Poonam
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  givenname: Poonam
  surname: Negi
  fullname: Negi, Poonam
  organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India
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  givenname: Murtaza M.
  surname: Tambuwala
  fullname: Tambuwala, Murtaza M.
  organization: School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, UK
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  givenname: Kamal
  surname: Dua
  fullname: Dua, Kamal
  organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India
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Keywords MUDA
CTAN
CPP
EDC
Sulfo-NHS
TPE
IgG
PVP
AGB1
CTAB
Sulfo-SMCC
SPDP
MPS
AMPs
APTMS
TBA
Nanopharmaceuticals
MB
NHS
MDR
FRET
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SATA
Bio-conjugation
SWCNT
PDP-PE
MIC
AgNPs
Cdna
PDPSA
RGD
TEOS
Bio-functionalize
PEG
ROS
Biosensors
PDP-PEG-DSPE
TCEP
MPA
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Snippet From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated...
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SubjectTerms AgNPs
Bio-conjugation
Bio-functionalize
Biosensors
Nanopharmaceuticals
Title Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery
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