Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery
From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologica...
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Published in | Colloid and interface science communications Vol. 35; p. 100244 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Elsevier B.V
01.03.2020
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Abstract | From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologically benevolent moieties that enhance the bio-acceptability of silver-based nanosystems, and supplementary functionalities for further extension of their unique applications. The clinical importance of AgNPs was established long ago, but their clinical utilization has been explored only recently with the phenomenon of bio-conjugation. The biomolecule-conjugated AgNPs present operable solutions for tedious clinical complications of the present era, such as multidrug resistance, designing of pharmaceuticals with improved bioavailability, superior drug delivery vehicles and in situ bio imaging of important metabolites that utilize the biomolecule-anchored surface engineered AgNPs. This review epigrammatically discusses some interesting clinical applications of surface conjugated AgNPs with biomolecules such as peptides, nucleic acids, amino acids and antibodies in the current nanopharmaceutical paradigm.
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•This review article highlights:•Surface functionalization of AgNPs prior to bioconjugation.•Bio-conjugation strategies for AgNPs.•Various clinical applications of bio-conjugated AgNPs. |
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AbstractList | From nanopharmaceutics to renewable energy, silver nanoparticles (AgNPs) present innumerable applications in the contemporary era. However, the associated toxicity to the biosystems limits their application. Effective utilization of AgNPs, therefore, requires their surface conjugation with biologically benevolent moieties that enhance the bio-acceptability of silver-based nanosystems, and supplementary functionalities for further extension of their unique applications. The clinical importance of AgNPs was established long ago, but their clinical utilization has been explored only recently with the phenomenon of bio-conjugation. The biomolecule-conjugated AgNPs present operable solutions for tedious clinical complications of the present era, such as multidrug resistance, designing of pharmaceuticals with improved bioavailability, superior drug delivery vehicles and in situ bio imaging of important metabolites that utilize the biomolecule-anchored surface engineered AgNPs. This review epigrammatically discusses some interesting clinical applications of surface conjugated AgNPs with biomolecules such as peptides, nucleic acids, amino acids and antibodies in the current nanopharmaceutical paradigm.
[Display omitted]
•This review article highlights:•Surface functionalization of AgNPs prior to bioconjugation.•Bio-conjugation strategies for AgNPs.•Various clinical applications of bio-conjugated AgNPs. |
ArticleNumber | 100244 |
Author | Bakshi, Hamid A. Sharma, Mousmee Gupta, Gaurav Sharma, Abhishek Kumar Kapoor, Deepak N. Dua, Kamal Tambuwala, Murtaza M. Kumar, Deepak Prasher, Parteek Chellappan, Dinesh Kumar Mudila, Harish Negi, Poonam |
Author_xml | – sequence: 1 givenname: Parteek surname: Prasher fullname: Prasher, Parteek organization: Department of Chemistry, University of Petroleum & Energy Studies, Dehradun 248007, India – sequence: 2 givenname: Mousmee surname: Sharma fullname: Sharma, Mousmee email: mousmee.sharma90@gmail.com organization: Department of Chemistry, Uttaranchal University, Dehradun 248007, India – sequence: 3 givenname: Harish surname: Mudila fullname: Mudila, Harish organization: Department of Chemistry, Lovely Professional University, Phagwara 144411, India – sequence: 4 givenname: Gaurav surname: Gupta fullname: Gupta, Gaurav organization: School of Pharmacy, Suresh Gyan Vihar University, Jagatpura 302 017, Jaipur, India – sequence: 5 givenname: Abhishek Kumar surname: Sharma fullname: Sharma, Abhishek Kumar organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India – sequence: 6 givenname: Deepak surname: Kumar fullname: Kumar, Deepak organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India – sequence: 7 givenname: Hamid A. surname: Bakshi fullname: Bakshi, Hamid A. organization: School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, UK – sequence: 8 givenname: Poonam surname: Negi fullname: Negi, Poonam organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India – sequence: 9 givenname: Deepak N. surname: Kapoor fullname: Kapoor, Deepak N. organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India – sequence: 10 givenname: Dinesh Kumar surname: Chellappan fullname: Chellappan, Dinesh Kumar organization: Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia – sequence: 11 givenname: Murtaza M. surname: Tambuwala fullname: Tambuwala, Murtaza M. organization: School of Pharmacy and Pharmaceutical Science, Ulster University, Coleraine, County Londonderry, Northern Ireland BT52 1SA, UK – sequence: 12 givenname: Kamal surname: Dua fullname: Dua, Kamal organization: School of Pharmaceutical Sciences, Shoolini University, Bajhol, Sultanpur, Solan, Himachal Pradesh 173 229, India |
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