Phlorotannins from brown algae: a review on their antioxidant mechanisms and applications in oxidative stress-mediated diseases

Phlorotannins are polyphenolic compounds that are exclusively derived from marine brown algae. The molecular structure of phlorotannins with numerous phenol rings endows them with excellent radical scavenging and antioxidant properties. Oxidative stress plays a central role in the pathogenesis of ma...

Full description

Saved in:

Bibliographic Details
Published in	Journal of applied phycology Vol. 35; no. 2; pp. 867 - 892
Main Authors	Phang, Shou Jin, Teh, Huey Xhin, Looi, Mee Lee, Arumugam, Bavani, Fauzi, Mh Busra, Kuppusamy, Umah Rani
Format	Journal Article
Language	English
Published	Dordrecht Springer Netherlands 01.04.2023 Springer Nature B.V
Subjects	Algae antioxidant activity Antioxidant properties Antioxidants Bioavailability Biocompatibility Biomedical and Life Sciences chemical structure Defence mechanisms diabetes Diabetes mellitus Diseases Drug carriers Drug delivery drugs Ecology Encapsulation Freshwater & Marine Ecology In vivo methods and tests Life Sciences Liver diseases Molecular structure Nanofibers Nanoparticles Neurodegenerative diseases Oxidation Oxidative stress Pathogenesis Phaeophyceae phenol Phenols phlorotannins Plant Physiology Plant Sciences Polyphenols Reactive oxygen species Scavenging Skin diseases therapeutics Oxidative stress Liver diseases Neurodegenerative diseases Anti-oxidant Skin diseases Diabetes Antioxidant Retinal diseases Phlorotannins Phaeophyceae
Online Access	Get full text
ISSN	0921-8971 1573-5176
DOI	10.1007/s10811-023-02913-4

Cover

Loading…

Abstract	Phlorotannins are polyphenolic compounds that are exclusively derived from marine brown algae. The molecular structure of phlorotannins with numerous phenol rings endows them with excellent radical scavenging and antioxidant properties. Oxidative stress plays a central role in the pathogenesis of many diseases, including neurodegenerative diseases, hepatic diseases, skin diseases, diabetes and retinal diseases. Therefore, phlorotannins have been explored as potential antioxidant compounds to counteract the oxidative damage induced during disease development. The antioxidant mechanisms of phlorotannins are not only limited to the direct scavenging of reactive oxygen species (ROS) but also via the inhibition of ROS production and the activation of antioxidant defence mechanisms. In this review, we highlight the antioxidant properties and mechanisms of action of phlorotannins in the context of several oxidative stress-mediated diseases using evidence from in vitro and in vivo studies. Despite the promising antioxidant potential of phlorotannins, their translational applications are hindered by the poor bioavailability and biostability. Hence, the encapsulation of phlorotannins into various drug carriers like nanoparticles and nanofibres has been greatly explored. Taken together, these findings propose phlorotannins as potential therapeutics in the advancement of current treatment available for different oxidative stress-mediated diseases.
AbstractList	Phlorotannins are polyphenolic compounds that are exclusively derived from marine brown algae. The molecular structure of phlorotannins with numerous phenol rings endows them with excellent radical scavenging and antioxidant properties. Oxidative stress plays a central role in the pathogenesis of many diseases, including neurodegenerative diseases, hepatic diseases, skin diseases, diabetes and retinal diseases. Therefore, phlorotannins have been explored as potential antioxidant compounds to counteract the oxidative damage induced during disease development. The antioxidant mechanisms of phlorotannins are not only limited to the direct scavenging of reactive oxygen species (ROS) but also via the inhibition of ROS production and the activation of antioxidant defence mechanisms. In this review, we highlight the antioxidant properties and mechanisms of action of phlorotannins in the context of several oxidative stress-mediated diseases using evidence from in vitro and in vivo studies. Despite the promising antioxidant potential of phlorotannins, their translational applications are hindered by the poor bioavailability and biostability. Hence, the encapsulation of phlorotannins into various drug carriers like nanoparticles and nanofibres has been greatly explored. Taken together, these findings propose phlorotannins as potential therapeutics in the advancement of current treatment available for different oxidative stress-mediated diseases.
Author	Phang, Shou Jin Arumugam, Bavani Fauzi, Mh Busra Teh, Huey Xhin Looi, Mee Lee Kuppusamy, Umah Rani
Author_xml	– sequence: 1 givenname: Shou Jin orcidid: 0000-0001-9037-7650 surname: Phang fullname: Phang, Shou Jin organization: Department of Biomedical Science, Faculty of Medicine, Universiti Malaya – sequence: 2 givenname: Huey Xhin orcidid: 0000-0002-6594-8455 surname: Teh fullname: Teh, Huey Xhin organization: Department of Biomedical Science, Faculty of Medicine, Universiti Malaya – sequence: 3 givenname: Mee Lee orcidid: 0000-0001-5415-6973 surname: Looi fullname: Looi, Mee Lee organization: Centre for Future Learning, Taylor’s University – sequence: 4 givenname: Bavani orcidid: 0000-0001-8313-567X surname: Arumugam fullname: Arumugam, Bavani organization: Department of Biomedical Science, Faculty of Medicine, Universiti Malaya – sequence: 5 givenname: Mh Busra orcidid: 0000-0001-6449-639X surname: Fauzi fullname: Fauzi, Mh Busra organization: Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia – sequence: 6 givenname: Umah Rani orcidid: 0000-0001-8900-7476 surname: Kuppusamy fullname: Kuppusamy, Umah Rani email: umah@um.edu.my organization: Department of Biomedical Science, Faculty of Medicine, Universiti Malaya
BookMark	eNp9kctqHDEQRUWwIePHD2QlyCabjvXqbim7YPICQ7KI10JS13hkuqWJSmPHq_x6NDOBgBdeFAWlc0uXumfkJOUEhLzh7D1nbLxCzjTnHROyleGyU6_Iivej7Ho-DidkxYzgnTYjf03OEO8ZY0ZzvSJ_fmzmXHJ1KcWEdF3yQn3Jj4m6-c7BB-pogYcIjzQnWjcQC3Wpxvw7Tq3TBcLGpYgLtvFE3XY7x-Dae9sVEz1gNT4AxVoAsVtgiq7CRKeI4BDwgpyu3Yxw-a-fk9vPn35ef-1uvn_5dv3xpguyF7ULU-9FM8yZ8iH4oITgEvzkJiN8P3nBBTNS9zqoXskQ2HpgQisz-F55DUKek3fHvduSf-0Aq10iBphnlyDv0O7hdp7BDA19-wy9z7uSmjsrRsOVFIPeU-JIhZIRC6zttsTFlSfLmd1nYo-Z2JaJPWRiVRPpZ6IQ6-Fctbg4vyyVRym2f9IdlP-uXlD9BeSzpJM
CitedBy_id	crossref_primary_10_3390_md22080352 crossref_primary_10_3390_md22080344 crossref_primary_10_3390_molecules28124839 crossref_primary_10_1007_s13770_023_00590_5 crossref_primary_10_3390_antiox14030250 crossref_primary_10_3390_antiox13091048 crossref_primary_10_1016_j_jplph_2024_154366 crossref_primary_10_1002_fsn3_4370 crossref_primary_10_3390_antiox13040409 crossref_primary_10_1016_j_algal_2024_103446 crossref_primary_10_3390_ijms26062749 crossref_primary_10_1007_s10068_024_01680_3 crossref_primary_10_3390_md21050285 crossref_primary_10_1080_10408398_2025_2464700 crossref_primary_10_1016_j_jhazmat_2024_135831 crossref_primary_10_1021_acssuschemeng_4c01611 crossref_primary_10_1016_j_aqrep_2024_102614 crossref_primary_10_1080_10408398_2023_2282669 crossref_primary_10_1016_j_foodchem_2024_142569 crossref_primary_10_3390_app131810048 crossref_primary_10_3390_md22120575 crossref_primary_10_3389_fmars_2024_1500778 crossref_primary_10_3390_antiox12040787
Cites_doi	10.1016/j.nbd.2012.10.011 10.1016/j.biocel.2009.11.009 10.1021/acschemneuro.7b00527 10.5607/en.2015.24.4.325 10.1016/j.febslet.2007.04.022 10.1155/2020/8878172 10.3390/antiox8120569 10.1155/2010/453892 10.1186/s40942-016-0033-z 10.1146/annurev-nutr-071811-150748 10.1371/journal.pone.0071178 10.1016/j.jsps.2015.03.013 10.4196/kjpp.2019.23.2.121 10.1016/bs.acc.2014.11.001 10.3390/molecules25194550 10.1007/s10811-007-9254-8 10.1111/phpp.12010 10.1016/j.febslet.2005.10.008 10.3390/md19110625 10.1038/s12276-020-0384-2 10.3390/antiox11071374 10.1007/s12010-012-9545-7 10.1016/j.exer.2010.08.013 10.1111/j.1365-3164.2011.01009.x 10.1016/j.algal.2021.102484 10.1002/term.3246 10.1016/j.rbmo.2014.03.002 10.1155/2016/7432797 10.1271/bbb.120096 10.1134/S106307401804003X 10.3390/md16090300 10.1007/s10059-012-2285-2 10.1080/15569527.2019.1613425 10.3390/md20040243 10.1016/j.fct.2010.03.001 10.3390/molecules191015638 10.4254/wjh.v12.i7.332 10.1155/2018/3654095 10.1016/j.cbpa.2010.12.009 10.1016/j.tiv.2009.11.002 10.1155/2019/9372182 10.1111/ijfs.13571 10.4014/jmb.1910.10068 10.1016/j.carbpol.2012.05.082 10.1080/10715762.2016.1209745 10.3390/cells11081312 10.1155/2019/2105607 10.1016/j.foodchem.2012.11.026 10.3390/md17040225 10.1016/j.fct.2012.12.012 10.4014/jmb.2012.12013 10.1105/tpc.113.111336 10.1016/j.etap.2012.08.003 10.1155/2017/4076518 10.4196/kjpp.2015.19.3.219 10.1155/2018/7635197 10.1016/j.freeradbiomed.2016.04.001 10.1039/b909988n 10.1007/s10811-014-0476-2 10.1016/j.biopha.2016.10.091 10.1016/j.carbpol.2020.116214 10.1016/j.freeradbiomed.2013.05.045 10.1007/s12272-012-1116-5 10.1155/2018/7857251 10.1007/s12010-014-1099-4 10.3389/fncel.2019.00528 10.1016/j.foodchem.2018.03.013 10.1016/j.pneurobio.2013.11.006 10.1155/2020/8609213 10.1016/j.fpsl.2019.100346 10.3390/md20060387 10.1007/978-3-319-56017-5_2 10.1111/ics.12728 10.1007/s10126-012-9459-y 10.7314/APJCP.2014.15.2.561 10.1016/j.fitote.2015.08.014 10.1074/jbc.M900322200 10.3390/molecules27041372 10.1007/s10811-022-02749-4 10.3389/fnhum.2021.722323 10.1002/tox.23080 10.1007/s13659-020-00293-7 10.1016/j.etap.2012.03.006 10.1074/jbc.M111.315432 10.1016/j.foodchem.2012.11.005 10.1016/j.pharmthera.2013.09.006 10.3390/ijms23158468 10.1111/jcmm.12857 10.1016/j.ygyno.2014.11.015 10.1016/j.tiv.2009.05.013 10.1371/journal.pone.0163433 10.1038/aps.2017.28 10.1128/MCB.00118-16 10.1021/jf300157w 10.1007/s11684-019-0729-1 10.3389/fncel.2020.581191 10.1007/s10068-012-0031-3 10.3748/wjg.v20.i25.8082 10.1002/jcb.24790 10.3390/nano6120235 10.1016/j.bbamcr.2018.02.010 10.1016/j.freeradbiomed.2013.07.022 10.3390/nu5072646 10.1371/journal.pone.0135686 10.1161/CIRCRESAHA.110.223545 10.1002/jcb.20668 10.1177/11779322221115436 10.1101/2020.09.04.283473 10.3390/ijms19123824 10.1039/C4CC04270K 10.1177/1934578X211056144 10.1007/s00210-019-01652-z 10.1016/j.jphs.2021.01.008 10.1038/s41573-021-00233-1
ContentType	Journal Article
Copyright	The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Copyright_xml	– notice: The Author(s), under exclusive licence to Springer Nature B.V. 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
DBID	AAYXX CITATION 3V. 7TN 7X2 8FE 8FH 8FK AEUYN AFKRA ATCPS AZQEC BBNVY BENPR BHPHI CCPQU DWQXO F1W GNUQQ H95 HCIFZ L.G LK8 M0K M7N M7P PHGZM PHGZT PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7S9 L.6
DOI	10.1007/s10811-023-02913-4
DatabaseName	CrossRef ProQuest Central (Corporate) Oceanic Abstracts Agricultural Science Collection ProQuest SciTech Collection ProQuest Natural Science Collection ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest One Sustainability ProQuest Central UK/Ireland Agricultural & Environmental Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection ProQuest One Community College ProQuest Central ASFA: Aquatic Sciences and Fisheries Abstracts ProQuest Central Student Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources SciTech Premium Collection Aquatic Science & Fisheries Abstracts (ASFA) Professional Biological Sciences Agricultural Science Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database ProQuest Central Premium ProQuest One Academic (New) ProQuest One Academic Middle East (New) ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef Agricultural Science Database Aquatic Science & Fisheries Abstracts (ASFA) Professional ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials SciTech Premium Collection ProQuest One Community College ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest One Sustainability Oceanic Abstracts Natural Science Collection ProQuest Central Korea Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection Biological Science Collection Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources ProQuest Central (New) ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection Biological Science Database ProQuest SciTech Collection ProQuest One Academic UKI Edition ASFA: Aquatic Sciences and Fisheries Abstracts ProQuest One Academic ProQuest Central (Alumni) ProQuest One Academic (New) AGRICOLA AGRICOLA - Academic
DatabaseTitleList	Agricultural Science Database AGRICOLA
Database_xml	– sequence: 1 dbid: BENPR name: ProQuest Databases url: https://www.proquest.com/central sourceTypes: Aggregation Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Agriculture Biology Ecology Botany
EISSN	1573-5176
EndPage	892
ExternalDocumentID	10_1007_s10811_023_02913_4
GroupedDBID	-4W -56 -5G -BR -EM -Y2 -~C -~X .86 .VR 06C 06D 0R~ 0VY 199 1N0 1OL 1SB 2.D 203 28- 29J 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 3-Y 30V 3SX 4.4 406 408 409 40D 40E 53G 5GY 5QI 5VS 67N 67Z 6NX 78A 7X2 8FE 8FH 8TC 8UJ 95- 95. 95~ 96X AABHQ AACDK AAHBH AAHNG AAIAL AAJBT AAJKR AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDBF ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABWNU ABXPI ACAOD ACBXY ACDTI ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACSNA ACUHS ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEUYN AEVLU AEXYK AFBBN AFEXP AFFNX AFGCZ AFKRA AFLOW AFQWF AFRAH AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG ATCPS AVWKF AXYYD AZFZN B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BSONS CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBLON EBS EIOEI EJD EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GXS H13 HCIFZ HF~ HG5 HG6 HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IXE IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LK8 LLZTM M0K M4Y M7P MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P PF0 PT4 PT5 QOK QOR QOS R4E R89 R9I RHV RNI RNS ROL RPX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SZN T13 T16 TEORI TSG TSK TSV TUC U2A U9L UG4 UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK6 WK8 XJT XOL YLTOR YQT Z45 Z5O Z7U Z7V Z7W Z7Z Z81 Z83 Z86 Z8O Z8P Z8Q Z8T Z8U Z8W ZMTXR ZOVNA ~A9 ~EX ~KM AAPKM AAYXX ABBRH ABDBE ABFSG ACSTC ADHKG ADXHL AEZWR AFDZB AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT 3V. 7TN 8FK ABRTQ AZQEC DWQXO F1W GNUQQ H95 L.G M7N PKEHL PQEST PQGLB PQQKQ PQUKI PRINS 7S9 L.6
ID	FETCH-LOGICAL-c352t-cd5b2818104bccbc42213ebdad92b5db212093858c4543cc0f6028496b54b8e23
IEDL.DBID	U2A
ISSN	0921-8971
IngestDate	Fri Jul 11 08:37:30 EDT 2025 Fri Jul 25 09:59:47 EDT 2025 Thu Apr 24 22:59:27 EDT 2025 Tue Jul 01 04:26:05 EDT 2025 Fri Feb 21 02:43:42 EST 2025
IsPeerReviewed	true
IsScholarly	true
Issue	2
Keywords	Oxidative stress Liver diseases Neurodegenerative diseases Anti-oxidant Skin diseases Diabetes Antioxidant Retinal diseases Phlorotannins Phaeophyceae
Language	English
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c352t-cd5b2818104bccbc42213ebdad92b5db212093858c4543cc0f6028496b54b8e23
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ORCID	0000-0001-6449-639X 0000-0001-9037-7650 0000-0001-8900-7476 0000-0001-8313-567X 0000-0001-5415-6973 0000-0002-6594-8455
PQID	2791432686
PQPubID	2034534
PageCount	26
ParticipantIDs	proquest_miscellaneous_2849897696 proquest_journals_2791432686 crossref_primary_10_1007_s10811_023_02913_4 crossref_citationtrail_10_1007_s10811_023_02913_4 springer_journals_10_1007_s10811_023_02913_4
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	20230400 2023-04-00 20230401
PublicationDateYYYYMMDD	2023-04-01
PublicationDate_xml	– month: 4 year: 2023 text: 20230400
PublicationDecade	2020
PublicationPlace	Dordrecht
PublicationPlace_xml	– name: Dordrecht
PublicationTitle	Journal of applied phycology
PublicationTitleAbbrev	J Appl Phycol
PublicationYear	2023
Publisher	Springer Netherlands Springer Nature B.V
Publisher_xml	– name: Springer Netherlands – name: Springer Nature B.V
References	Joo, Kim, Lee, Kim, Koo, Kim (CR39) 2016; 36 Shibata, Ishimaru, Kawaguchi, Yoshikawa, Hama (CR97) 2008; 20 Wen, Aki, Unuma, Uemura (CR108) 2020; 14 Satoh, McKercher, Lipton (CR96) 2013; 65 Hauser, Hastings (CR30) 2013; 51 Lee, Shin, Utsuki, Choi, Byun, Kim (CR60) 2012; 60 Heo, Ko, Cha, Kang, Park, Choi, Kim, Jung, Jeon (CR31) 2009; 23 Park, Kim, Jang, Yang, Kim (CR81) 2018; 257 Lee, Seok, Boo (CR63) 2018; 2018 Cui, Park, Wu, Lee, Yang, Kang, Jung, Park, Yoo, Kim, Ahn Jo, Suk, Eun (CR21) 2015; 19 Kang, Lee, Chae, Zhang, Jung, Ham, Baik, Lee, Hyun (CR43) 2006; 97 Chen, Liu, Zhao, Qiu (CR17) 2021; 43 Robledinos-Antón, Fernández-Ginés, Manda, Cuadrado (CR89) 2019; 2019 Chen, Xu, Yan, Zhou, Jiang, Melcher, Xu (CR16) 2017; 38 Kang, Cha, Wijesinghe, Kang, Lee, Kim, Song, Jeon (CR46) 2013; 138 Tong, Liu, Yu (CR102) 2021; 19 Parker, Crouch (CR84) 2010; 91 Zhang, Li, Wu, Nice, Huang, Zhang (CR115) 2020; 14 Kumar, Paul, Anas, Tejpal, Chatterjee, Anupama, Mathew, Ravishankar (CR56) 2022; 34 Zafar, Ahmed, Khan (CR114) 2016; 50 Saari (CR93) 2012; 32 de Jager, Cockrell, Du Plessis (CR25) 2017; 996 Wang, Hung, Lin, Fang, Yang, Chen, Pan (CR107) 2019; 8 Abe, Morita (CR1) 2010; 27 Liu, Chen, Zhang (CR65) 2022; 27 Kaneto, Katakami, Matsuhisa, Matsuoka (CR41) 2010; 2010 Park, Cha, Hong, Kim, Kim, Kim, Kim, Jeon, Choi (CR82) 2019; 17 Mailloux (CR67) 2018; 2018 Nishimura, Hara, Kondo, Hong, Matsugi (CR73) 2017; 2017 Bresciani, da Cruz, González-Gallego (CR10) 2015; 68 Yaribeygi, Sathyapalan, Atkin, Sahebkar (CR112) 2020; 2020 Kim, Kang, Shin, Bak, Lee, Lee, Yoo, Kim, Lee, Kim, Lee, Jo, Yuk (CR54) 2016; 11 Heo, Ko, Kang, Cha, Lee, Kang, Jung, Affan, Oh, Jeon (CR32) 2010; 48 CR57 Hussain, Tan, Yin, Blachier, Tossou, Rahu (CR36) 2016; 2016 Kim, Kang, Piao, Kim, Zheng, Yao, Cha, Hyun, Kang, Lee, Hyun (CR52) 2014; 115 Cha, Ko, Kim, Jeon (CR12) 2012; 23 Ng, Lee (CR71) 2019; 13 Lee, Choi, Heo, Park, Park, Jeon, Kim, Han, Jeon (CR62) 2012; 21 Bai, Sun, Gu, Zheng, Yu, Qi (CR5) 2020; 25 Meslet-Cladière, Delage, Leroux, Goulitquer, Leblanc, Creis, Gall, Stiger-Pouvreau, Czjzek, Potin (CR69) 2013; 25 Rushworth, Megson (CR91) 2014; 141 Cha, Hwang, Heo, Jun (CR13) 2018; 2018 Chukwuma, Nworah, Apeh, Omeje, Nweze, Asogwa, Ezeorba (CR18) 2022; 16 Besednova, Andryukov, Zaporozhets, Kuznetsova, Kryzhanovsky, Ermakova, Galkina, Shchelkanov (CR8) 2022; 20 Chen, Okano, Maeda, Chauhan, Golczak, Maeda, Palczewski (CR15) 2012; 287 Bellezza, Giambanco, Minelli, Donato (CR7) 2018; 5 Park, Heo, Kim, Ahn, Park, Moon, Jeon, Lee (CR80) 2015; 106 Park, Lee, Hong, Kim, Park, Jeong, Kim, Hyun, Yun, Kim, Kim, Choi (CR83) 2019; 38 Monteiro, Lomartire, Cotas, Marques, Pereira, Gonçalves (CR70) 2022; 20 Cui, Amarsanaa, Lee, Rhim, Kwon, Kim, Park, Jung, Eun (CR22) 2019; 23 Forman, Davies, Ursini (CR26) 2014; 66 Giacco, Brownlee (CR28) 2010; 107 Phang, Arumugam, Kuppusamy, Fauzi, Looi (CR88) 2021; 15 Lee, Han, Heo, Hwang, Jeon (CR59) 2010; 24 Twarda-Clapa, Olczak, Białkowska, Koziołkiewicz (CR104) 2022; 11 Heo, Cha, Kim, Lee, Ahn, Kang, Oh, Choi, Affan, Kim, Jeon (CR33) 2012; 166 Shin, Kim, Park, Lee, Cho, Choi, Heo, Kim, Kim (CR98) 2021; 31 Perillo, Di Donato, Pezone, Di Zazzo, Giovannelli, Galasso, Castoria, Migliaccio (CR86) 2020; 52 Cichoż-Lach, Michalak (CR20) 2014; 20 Yoon, Lee, Sim, Lim, Lee, Cho (CR113) 2013; 16 Lai, Zhang, Wang (CR58) 2014; 115 Ryu, Zhang, Hong, Yang, Kang, Choi, Kim, Noh, Kim, Lee, Hyun, Kim (CR92) 2013; 8 CR76 Kim, Kim (CR48) 2012; 90 CR111 Pal (CR77) 2021; 15 Al-Gubory (CR3) 2014; 29 Kang, Wijesinghe, Lee, Kang, Ko, Yang, Kang, Jeon, Kim, Lee, Jeon (CR47) 2013; 53 Huang, Lu, Ding (CR34) 2021; 11 Asmat, Abad, Ismail (CR4) 2016; 24 Zhu, Sun, Zhang, Su, Luo, Alarifi, Yang (CR116) 2021; 36 Cui, Yang, Abdel-Samie, Lin (CR23) 2020; 239 Park, Heo, Park, Moon, Sung, Jeon, Lee (CR79) 2014; 174 Sadeeshkumar, Duraikannu, Ravichandran, Fredrick, Sivaperumal, Kodisundaram (CR94) 2016; 84 Dang, Bowyer, Van Altena, Scarlett (CR24) 2018; 53 Kang, Lee, Park, Lee, Na, Surh, You, Chung, Hyun (CR44) 2007; 581 Balboa, Conde, Moure, Falqué, Domínguez (CR6) 2013; 138 Charoensiddhi, Franco, Su, Zhang (CR14) 2015; 27 Park, Kim, Jeon (CR78) 2012; 33 Ruia, Saxena, Prasad, Sharma, Akduman, Khanna (CR90) 2016; 2 Imbs, Zvyagintseva (CR37) 2018; 44 Yang, Ahn, Ryu, Choi, Choi, Chong, Hyun, Chang, Kim (CR109) 2015; 10 Kim, Kim, Rhie, Yoon (CR53) 2015; 24 Lee, Park, Kang, Ko, Kang, Cho, Park, Jeon, Kim, Han, Jeon (CR61) 2012; 76 Wang, Zheng, Huang, Zhao, Lin, Zhou, Naman, Wang, Gerwick, Wang, Yan, Cui, He (CR106) 2018; 9 Jun, Lee, Shin, Yoon, Kim, Kim (CR40) 2014; 19 Cenini, Lloret, Cascella (CR11) 2019; 2019 Meng, Mu, Sun, Garcia-Vaquero (CR68) 2021; 60 Jang, Ye, Heo, Oh, Kang, Kim, Affan, Yoon, Choi, Park, Han, Qian, Jung, Choi (CR38) 2012; 34 Brand (CR9) 2016; 100 Perusek, Maeda (CR87) 2013; 5 Nho, Shin, Jeong, Cho, Heo, Kim, Kim (CR72) 2020; 30 Kruk, Duchnik (CR55) 2014; 15 Kim, Kim, Kang, Jeon, Um, Jung (CR50) 2012; 14 Tsermpini, Plemenitaš Ilješ, Dolžan (CR103) 2022; 11 CR95 Kang, Cha, Ko, Kang, Kim, Heo, Kim, Heu, Kim, Jung, Jeon (CR45) 2012; 34 Pasupuleti, Arigela, Gan, Salam, Krishnan, Rahman, Jeffree (CR85) 2020; 2020 Kim, Kang, Zhang, Piao, Kim, Kang, Lee, Lee, Surh, Hyun (CR49) 2010; 42 Hur, Gray (CR35) 2011; 15 Kang, Lee, Chae, Zhang, Jung, Lee, Kim, Kim, Joo, Park, Ham, Lee, Hyun (CR42) 2005; 579 CR29 Ahn, Moon, Kim, Jung, Choi (CR2) 2012; 35 CR27 Maeda, Maeda, Golczak, Chou, Desai, Hoppel, Matsuyama, Palczewski (CR66) 2009; 284 Yang, Ahn, Choi, Choi (CR110) 2015; 136 Tan, Yates, Lilly, Dhanda (CR100) 2020; 12 CR101 Kim, Piao, Cho, Lee, Hyun (CR51) 2012; 28 Venkatesan, Kim, Shim (CR105) 2016; 6 Okagu, Ezeorba, Aguchem, Ohanenye, Aham, Okafor, Bollati, Lammi (CR74) 2022; 23 Li, Liu, Zhang, Chen, Zhu, Wang (CR64) 2018; 16 Cia, Cubizolle, Crauste, Jacquemot, Guillou, Vigor, Angebault, Hamel, Vercauteren, Brabet (CR19) 2016; 20 Surendhiran, Cui, Lin (CR99) 2019; 21 Okagu, Ezeorba, Aham, Aguchem, Nechi (CR75) 2022; 4 TL de Jager (2913_CR25) 2017; 996 KC Kim (2913_CR51) 2012; 28 SY Ng (2913_CR71) 2019; 13 S-J Heo (2913_CR31) 2009; 23 M-S Lee (2913_CR60) 2012; 60 L Meslet-Cladière (2913_CR69) 2013; 25 K-A Kim (2913_CR50) 2012; 14 TI Imbs (2913_CR37) 2018; 44 AD Kim (2913_CR52) 2014; 115 S Li (2913_CR64) 2018; 16 S Ruia (2913_CR90) 2016; 2 P Zhang (2913_CR115) 2020; 14 M Kim (2913_CR48) 2012; 90 GF Rushworth (2913_CR91) 2014; 141 J Wang (2913_CR106) 2018; 9 KA Kang (2913_CR44) 2007; 581 V Sadeeshkumar (2913_CR94) 2016; 84 JA Nho (2913_CR72) 2020; 30 I Bellezza (2913_CR7) 2018; 5 MM Pal (2913_CR77) 2021; 15 J-J Kim (2913_CR54) 2016; 11 S-J Heo (2913_CR33) 2012; 166 M-H Park (2913_CR80) 2015; 106 2913_CR27 H Cui (2913_CR23) 2020; 239 SJ Park (2913_CR78) 2012; 33 I Abe (2913_CR1) 2010; 27 2913_CR29 VR Pasupuleti (2913_CR85) 2020; 2020 S-H Cha (2913_CR12) 2012; 23 W Meng (2913_CR68) 2021; 60 M-C Kang (2913_CR47) 2013; 53 S Wen (2913_CR108) 2020; 14 Y Nishimura (2913_CR73) 2017; 2017 H Kaneto (2913_CR41) 2010; 2010 M-H Park (2913_CR79) 2014; 174 2913_CR95 2913_CR111 TT Dang (2913_CR24) 2018; 53 J Jang (2913_CR38) 2012; 34 J-w Lee (2913_CR63) 2018; 2018 BR Ahn (2913_CR2) 2012; 35 Y Cui (2913_CR21) 2015; 19 L Perusek (2913_CR87) 2013; 5 T Hussain (2913_CR36) 2016; 2016 IU Okagu (2913_CR74) 2022; 23 Y Chen (2913_CR15) 2012; 287 P-W Wang (2913_CR107) 2019; 8 YS Shin (2913_CR98) 2021; 31 Y-I Yang (2913_CR110) 2015; 136 GF Chen (2913_CR16) 2017; 38 Y-J Jun (2913_CR40) 2014; 19 C Park (2913_CR82) 2019; 17 X Zhu (2913_CR116) 2021; 36 S-H Lee (2913_CR59) 2010; 24 IF Chukwuma (2913_CR18) 2022; 16 H Yaribeygi (2913_CR112) 2020; 2020 2913_CR101 EE Tsermpini (2913_CR103) 2022; 11 P Liu (2913_CR65) 2022; 27 W Hur (2913_CR35) 2011; 15 JC Saari (2913_CR93) 2012; 32 D Surendhiran (2913_CR99) 2019; 21 KA Kang (2913_CR43) 2006; 97 C Park (2913_CR83) 2019; 38 J Ryu (2913_CR92) 2013; 8 S Charoensiddhi (2913_CR14) 2015; 27 A Maeda (2913_CR66) 2009; 284 NN Besednova (2913_CR8) 2022; 20 G Cenini (2913_CR11) 2019; 2019 LRG Kumar (2913_CR56) 2022; 34 SR Park (2913_CR81) 2018; 257 A Twarda-Clapa (2913_CR104) 2022; 11 Y Cui (2913_CR22) 2019; 23 F Giacco (2913_CR28) 2010; 107 2913_CR76 KC Kim (2913_CR49) 2010; 42 RJ Mailloux (2913_CR67) 2018; 2018 T Satoh (2913_CR96) 2013; 65 S-H Cha (2913_CR13) 2018; 2018 DN Hauser (2913_CR30) 2013; 51 GH Kim (2913_CR53) 2015; 24 KA Kang (2913_CR42) 2005; 579 MS Joo (2913_CR39) 2016; 36 J Kruk (2913_CR55) 2014; 15 D Cia (2913_CR19) 2016; 20 E-J Yang (2913_CR109) 2015; 10 M-C Kang (2913_CR46) 2013; 138 S Zafar (2913_CR114) 2016; 50 J Chen (2913_CR17) 2021; 43 TW Lai (2913_CR58) 2014; 115 H Cichoż-Lach (2913_CR20) 2014; 20 SJ Phang (2913_CR88) 2021; 15 G Bresciani (2913_CR10) 2015; 68 J Venkatesan (2913_CR105) 2016; 6 IU Okagu (2913_CR75) 2022; 4 Y Bai (2913_CR5) 2020; 25 B Perillo (2913_CR86) 2020; 52 RO Parker (2913_CR84) 2010; 91 SH Lee (2913_CR62) 2012; 21 2913_CR57 N Robledinos-Antón (2913_CR89) 2019; 2019 U Asmat (2913_CR4) 2016; 24 M Huang (2913_CR34) 2021; 11 MD Brand (2913_CR9) 2016; 100 SJ Heo (2913_CR32) 2010; 48 T Shibata (2913_CR97) 2008; 20 KH Al-Gubory (2913_CR3) 2014; 29 S-M Kang (2913_CR45) 2012; 34 EM Balboa (2913_CR6) 2013; 138 NY Yoon (2913_CR113) 2013; 16 HJ Forman (2913_CR26) 2014; 66 S-H Lee (2913_CR61) 2012; 76 T Tong (2913_CR102) 2021; 19 HK Tan (2913_CR100) 2020; 12 P Monteiro (2913_CR70) 2022; 20
References_xml	– volume: 51 start-page: 35 year: 2013 end-page: 42 ident: CR30 article-title: Mitochondrial dysfunction and oxidative stress in Parkinson's disease and monogenic parkinsonism publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2012.10.011 – volume: 42 start-page: 297 year: 2010 end-page: 305 ident: CR49 article-title: Up-regulation of Nrf2-mediated heme oxygenase-1 expression by eckol, a phlorotannin compound, through activation of Erk and PI3K/Akt publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2009.11.009 – volume: 9 start-page: 1349 year: 2018 end-page: 1356 ident: CR106 article-title: Eckmaxol, a phlorotannin extracted from , produces anti-β-amyloid oligomer neuroprotective effects possibly via directly acting on glycogen synthase kinase 3β publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.7b00527 – volume: 24 start-page: 325 year: 2015 end-page: 340 ident: CR53 article-title: The role of oxidative stress in neurodegenerative diseases publication-title: Exp Neurobiol doi: 10.5607/en.2015.24.4.325 – volume: 581 start-page: 2000 year: 2007 end-page: 2008 ident: CR44 article-title: Triphlorethol-A induces heme oxygenase-1 via activation of ERK and NF-E2 related factor 2 transcription factor publication-title: FEBS Lett doi: 10.1016/j.febslet.2007.04.022 – volume: 2020 start-page: 8878172 year: 2020 ident: CR85 article-title: A review on oxidative stress, diabetic complications, and the roles of honey polyphenols publication-title: Oxid Med Cell Longev doi: 10.1155/2020/8878172 – volume: 8 start-page: 569 year: 2019 ident: CR107 article-title: Comparison of the biological impact of UVA and UVB upon the skin with functional proteomics and immunohistochemistry publication-title: Antioxidants doi: 10.3390/antiox8120569 – volume: 2010 year: 2010 ident: CR41 article-title: Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis publication-title: Mediators Inflamm doi: 10.1155/2010/453892 – volume: 2 start-page: 8 year: 2016 ident: CR90 article-title: Correlation of biomarkers thiobarbituric acid reactive substance, nitric oxide and central subfield and cube average thickness in diabetic retinopathy: a cross-sectional study publication-title: Int J Retin Vitr doi: 10.1186/s40942-016-0033-z – volume: 32 start-page: 125 year: 2012 end-page: 145 ident: CR93 article-title: Vitamin A metabolism in rod and cone visual cycles publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071811-150748 – volume: 8 year: 2013 ident: CR92 article-title: Phloroglucinol attenuates motor functional deficits in an animal model of Parkinson's disease by enhancing Nrf2 activity publication-title: PLoS ONE doi: 10.1371/journal.pone.0071178 – ident: CR101 – volume: 24 start-page: 547 year: 2016 end-page: 553 ident: CR4 article-title: Diabetes mellitus and oxidative stress-a concise review publication-title: Saudi Pharm J doi: 10.1016/j.jsps.2015.03.013 – volume: 23 start-page: 121 year: 2019 end-page: 130 ident: CR22 article-title: Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2/heme oxygenase-1 pathway publication-title: Korean J Physiol Pharmacol doi: 10.4196/kjpp.2019.23.2.121 – volume: 68 start-page: 87 year: 2015 end-page: 130 ident: CR10 article-title: Manganese superoxide dismutase and oxidative stress modulation publication-title: Adv Clin Chem doi: 10.1016/bs.acc.2014.11.001 – volume: 25 start-page: 4550 year: 2020 ident: CR5 article-title: Preparation, characterization and antioxidant activities of kelp phlorotannin nanoparticles publication-title: Molecules doi: 10.3390/molecules25194550 – volume: 20 start-page: 705 year: 2008 end-page: 711 ident: CR97 article-title: Antioxidant activities of phlorotannins isolated from Japanese Laminariaceae publication-title: J Appl Phycol doi: 10.1007/s10811-007-9254-8 – volume: 28 start-page: 322 year: 2012 end-page: 331 ident: CR51 article-title: Phloroglucinol protects human keratinocytes from ultraviolet B radiation by attenuating oxidative stress publication-title: Photodermatol Photoimmunol Photomed doi: 10.1111/phpp.12010 – ident: CR57 – volume: 579 start-page: 6295 year: 2005 end-page: 6304 ident: CR42 article-title: Eckol isolated from attenuates oxidative stress induced cell damage in lung fibroblast cells publication-title: FEBS Lett doi: 10.1016/j.febslet.2005.10.008 – volume: 19 start-page: 625 year: 2021 ident: CR102 article-title: Extraction and nano-sized delivery systems for phlorotannins to improve its bioavailability and bioactivity publication-title: Mar Drugs doi: 10.3390/md19110625 – volume: 52 start-page: 192 year: 2020 end-page: 203 ident: CR86 article-title: ROS in cancer therapy: the bright side of the moon publication-title: Exp Mol Med doi: 10.1038/s12276-020-0384-2 – volume: 11 start-page: 1374 year: 2022 ident: CR103 article-title: Alcohol-induced oxidative stress and the role of antioxidants in alcohol use disorder: a systematic review publication-title: Antioxidants doi: 10.3390/antiox11071374 – volume: 166 start-page: 1520 year: 2012 end-page: 1532 ident: CR33 article-title: Neuroprotective effect of phlorotannin isolated from against H O -induced oxidative stress in murine hippocampal neuronal cells, HT22 publication-title: Appl Biochem Biotechnol doi: 10.1007/s12010-012-9545-7 – volume: 91 start-page: 788 year: 2010 end-page: 792 ident: CR84 article-title: Retinol dehydrogenases (RDHs) in the visual cycle publication-title: Exp Eye Res doi: 10.1016/j.exer.2010.08.013 – volume: 23 start-page: 51 year: 2012 ident: CR12 article-title: Protective effects of phlorotannins against ultraviolet B radiation in zebrafish ( ) publication-title: Vet Dermatol doi: 10.1111/j.1365-3164.2011.01009.x – volume: 60 year: 2021 ident: CR68 article-title: Phlorotannins: a review of extraction methods, structural characteristics, bioactivities, bioavailability, and future trends publication-title: Algal Res doi: 10.1016/j.algal.2021.102484 – volume: 15 start-page: 1051 year: 2021 end-page: 1068 ident: CR88 article-title: A review of diabetic wound models—novel insights into diabetic foot ulcer publication-title: J Tissue Eng Regen Med doi: 10.1002/term.3246 – volume: 29 start-page: 17 year: 2014 end-page: 31 ident: CR3 article-title: Environmental pollutants and lifestyle factors induce oxidative stress and poor prenatal development publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2014.03.002 – volume: 2016 start-page: 7432797 year: 2016 ident: CR36 article-title: Oxidative stress and inflammation: what polyphenols can do for us? publication-title: Oxid Med Cell Longev doi: 10.1155/2016/7432797 – volume: 76 start-page: 1445 year: 2012 end-page: 1451 ident: CR61 article-title: Dieckol isolated from protects against high-glucose induced damage to rat insulinoma cells by reducing oxidative stress and apoptosis publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.120096 – volume: 44 start-page: 263 year: 2018 end-page: 273 ident: CR37 article-title: Phlorotannins are polyphenolic metabolites of brown algae publication-title: Russ J Mar Biol doi: 10.1134/S106307401804003X – volume: 16 start-page: 300 year: 2018 ident: CR64 article-title: Protective effect of eckol against acute hepatic injury induced by carbon tetrachloride in mice publication-title: Mar Drugs doi: 10.3390/md16090300 – volume: 33 start-page: 363 year: 2012 end-page: 369 ident: CR78 article-title: Antioxidant dieckol downregulates the Rac1/ROS signaling pathway and inhibits Wiskott-Aldrich syndrome protein (WASP)-family verprolin-homologous protein 2 (WAVE2)-mediated invasive migration of B16 mouse melanoma cells publication-title: Mol Cells doi: 10.1007/s10059-012-2285-2 – volume: 38 start-page: 298 year: 2019 end-page: 308 ident: CR83 article-title: Protective effect of diphlorethohydroxycarmalol against oxidative stress-induced DNA damage and apoptosis in retinal pigment epithelial cells publication-title: Cutan Ocul Toxicol doi: 10.1080/15569527.2019.1613425 – volume: 20 start-page: 243 year: 2022 ident: CR8 article-title: Molecular targets of brown algae phlorotannins for the therapy of inflammatory processes of various origins publication-title: Mar Drugs doi: 10.3390/md20040243 – volume: 48 start-page: 1355 year: 2010 end-page: 1361 ident: CR32 article-title: Inhibitory effect of diphlorethohydroxycarmalol on melanogenesis and its protective effect against UV-B radiation-induced cell damage publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2010.03.001 – volume: 19 start-page: 15638 year: 2014 end-page: 15652 ident: CR40 article-title: Eckol enhances heme oxygenase-1 expression through activation of Nrf2/JNK pathway in HepG2 cells publication-title: Molecules doi: 10.3390/molecules191015638 – volume: 12 start-page: 332 year: 2020 end-page: 349 ident: CR100 article-title: Oxidative stress in alcohol-related liver disease publication-title: World J Hepatol doi: 10.4254/wjh.v12.i7.332 – ident: CR27 – volume: 2018 start-page: 3654095 year: 2018 ident: CR13 article-title: Diphlorethohydroxycarmalol attenuates methylglyoxal-induced oxidative stress and advanced glycation end product formation in human kidney cells publication-title: Oxid Med Cell Longev doi: 10.1155/2018/3654095 – volume: 15 start-page: 162 year: 2011 end-page: 173 ident: CR35 article-title: Small molecule modulators of antioxidant response pathway publication-title: Curr Opin Chem Biol doi: 10.1016/j.cbpa.2010.12.009 – volume: 24 start-page: 375 year: 2010 end-page: 381 ident: CR59 article-title: Protective effects of dieckol isolated from against high glucose-induced oxidative stress in human umbilical vein endothelial cells publication-title: Toxicol in Vitro doi: 10.1016/j.tiv.2009.11.002 – volume: 2019 start-page: 9372182 year: 2019 ident: CR89 article-title: Activators and inhibitors of NRF2: a review of their potential for clinical development publication-title: Oxid Med Cell Longev doi: 10.1155/2019/9372182 – volume: 53 start-page: 174 year: 2018 end-page: 181 ident: CR24 article-title: Comparison of chemical profile and antioxidant properties of the brown algae publication-title: Int J Food Sci Technol doi: 10.1111/ijfs.13571 – volume: 30 start-page: 359 year: 2020 end-page: 367 ident: CR72 article-title: Neuroprotective effects of phlorotannin-rich extract from brown seaweed on neuronal PC-12 and SH-SY5Y cells with oxidative stress publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.1910.10068 – volume: 90 start-page: 592 year: 2012 end-page: 601 ident: CR48 article-title: Electrospun PCL/phlorotannin nanofibres for tissue engineering: physical properties and cellular activities publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2012.05.082 – volume: 50 start-page: 939 year: 2016 end-page: 948 ident: CR114 article-title: Biotransformation: a green and efficient way of antioxidant synthesis publication-title: Free Radic Res doi: 10.1080/10715762.2016.1209745 – volume: 11 start-page: 1312 year: 2022 ident: CR104 article-title: Advanced glycation end-products (AGEs): formation, chemistry, classification, receptors, and diseases related to AGEs publication-title: Cells doi: 10.3390/cells11081312 – volume: 2019 start-page: 2105607 year: 2019 ident: CR11 article-title: Oxidative stress in neurodegenerative diseases: from a mitochondrial point of view publication-title: Oxid Med Cell Longev doi: 10.1155/2019/2105607 – volume: 138 start-page: 1764 year: 2013 end-page: 1785 ident: CR6 article-title: antioxidant properties of crude extracts and compounds from brown algae publication-title: Food Chem doi: 10.1016/j.foodchem.2012.11.026 – volume: 17 start-page: 225 year: 2019 ident: CR82 article-title: Protective effect of phloroglucinol on oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2/HO-1 signaling pathway in HaCaT human keratinocytes publication-title: Mar Drugs doi: 10.3390/md17040225 – volume: 53 start-page: 294 year: 2013 end-page: 298 ident: CR47 article-title: Dieckol isolated from brown seaweed attenuates type II diabetes in db/db mouse model publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2012.12.012 – volume: 31 start-page: 584 year: 2021 end-page: 591 ident: CR98 article-title: Effects of extract on neuronal damage and apoptosis in PC-12 cells against oxidative stress publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.2012.12013 – volume: 25 start-page: 3089 year: 2013 end-page: 3103 ident: CR69 article-title: Structure/function analysis of a type III polyketide synthase in the brown alga reveals a biochemical pathway in phlorotannin monomer biosynthesis publication-title: Plant Cell doi: 10.1105/tpc.113.111336 – volume: 34 start-page: 926 year: 2012 end-page: 934 ident: CR38 article-title: Photo-oxidative stress by ultraviolet-B radiation and antioxidative defense of eckstolonol in human keratinocytes publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2012.08.003 – volume: 2017 start-page: 4076518 year: 2017 ident: CR73 article-title: Oxidative stress in retinal diseases publication-title: Oxid Med Cell Longev doi: 10.1155/2017/4076518 – volume: 19 start-page: 219 year: 2015 end-page: 228 ident: CR21 article-title: Dieckol attenuates microglia-mediated neuronal cell death via ERK, Akt and NADPH oxidase-mediated pathways publication-title: Korean J Physiol Pharmacol doi: 10.4196/kjpp.2015.19.3.219 – volume: 2018 start-page: 1 year: 2018 end-page: 12 ident: CR63 article-title: extract and dieckol attenuate cellular lipid peroxidation in keratinocytes exposed to PM10 publication-title: Evid Based Complement Alternat Med doi: 10.1155/2018/7635197 – volume: 100 start-page: 14 year: 2016 end-page: 31 ident: CR9 article-title: Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2016.04.001 – volume: 27 start-page: 809 year: 2010 end-page: 838 ident: CR1 article-title: Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases publication-title: Nat Prod Rep doi: 10.1039/b909988n – volume: 27 start-page: 2049 year: 2015 end-page: 2058 ident: CR14 article-title: Improved antioxidant activities of brown seaweed extracts prepared by microwave-assisted enzymatic extraction publication-title: J Appl Phycol doi: 10.1007/s10811-014-0476-2 – volume: 84 start-page: 1810 year: 2016 end-page: 1819 ident: CR94 article-title: Protective effects of dieckol on -nitrosodiethylamine induced hepatocarcinogenesis in rats publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.10.091 – volume: 239 year: 2020 ident: CR23 article-title: Cold plasma treated phlorotannin/ polysaccharide nanofiber for active food packaging publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2020.116214 – volume: 66 start-page: 24 year: 2014 end-page: 35 ident: CR26 article-title: How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.05.045 – volume: 35 start-page: 1989 year: 2012 end-page: 1998 ident: CR2 article-title: Neuroprotective effect of edible brown alga on amyloid beta peptide-induced toxicity in PC12 cells publication-title: Arch Pharm Res doi: 10.1007/s12272-012-1116-5 – ident: CR111 – ident: CR29 – volume: 2018 start-page: 7857251 year: 2018 ident: CR67 article-title: Mitochondrial antioxidants and the maintenance of cellular hydrogen peroxide levels publication-title: Oxid Med Cell Longev doi: 10.1155/2018/7857251 – volume: 174 start-page: 632 year: 2014 end-page: 643 ident: CR79 article-title: 6,6'-bieckol isolated from protects oxidative stress through inhibiting expression of ROS and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells publication-title: Appl Biochem Biotechnol doi: 10.1007/s12010-014-1099-4 – volume: 13 start-page: 528 year: 2019 ident: CR71 article-title: Traumatic brain injuries: pathophysiology and potential therapeutic targets publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00528 – volume: 257 start-page: 128 year: 2018 end-page: 134 ident: CR81 article-title: Inhibitory activity of minor phlorotannins from on α-glucosidase publication-title: Food Chem doi: 10.1016/j.foodchem.2018.03.013 – volume: 115 start-page: 157 year: 2014 end-page: 188 ident: CR58 article-title: Excitotoxicity and stroke: identifying novel targets for neuroprotection publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2013.11.006 – volume: 2020 start-page: 8609213 year: 2020 ident: CR112 article-title: Molecular mechanisms linking oxidative stress and diabetes mellitus publication-title: Oxid Med Cell Longev doi: 10.1155/2020/8609213 – volume: 21 year: 2019 ident: CR99 article-title: Encapsulation of phlorotannin in Alginate/PEO blended nanofibers to preserve chicken meat from contaminations publication-title: Food Packag Shelf Life doi: 10.1016/j.fpsl.2019.100346 – volume: 20 start-page: 387 year: 2022 ident: CR70 article-title: Call the eckols: present and future potential cancer therapies publication-title: Mar Drugs doi: 10.3390/md20060387 – volume: 4 year: 2022 ident: CR75 article-title: Recent findings on the cellular and molecular mechanisms of action of novel food-derived antihypertensive peptides publication-title: Food Chem: Mol Sci – volume: 16 start-page: 1 year: 2013 end-page: 5 ident: CR113 article-title: Quinone reductase induction activity of phlorotannins derived from in Hepa1c1c7 cells publication-title: Fish Aquatic Sci – volume: 996 start-page: 15 year: 2017 end-page: 23 ident: CR25 article-title: Ultraviolet light induced generation of reactive oxygen species publication-title: Adv Exp Med Biol doi: 10.1007/978-3-319-56017-5_2 – volume: 43 start-page: 495 year: 2021 end-page: 509 ident: CR17 article-title: Oxidative stress in the skin: impact and related protection publication-title: Int J Cosmet Sci doi: 10.1111/ics.12728 – volume: 14 start-page: 383 year: 2012 end-page: 395 ident: CR50 article-title: Edible seaweed, , protects retinal ganglion cells death caused by oxidative stress publication-title: Mar Biotechnol (NY) doi: 10.1007/s10126-012-9459-y – volume: 15 start-page: 561 year: 2014 end-page: 568 ident: CR55 article-title: Oxidative stress and skin diseases: possible role of physical activity publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2014.15.2.561 – volume: 106 start-page: 135 year: 2015 end-page: 140 ident: CR80 article-title: 6,6’-bieckol protects insulinoma cells against high glucose-induced glucotoxicity by reducing oxidative stress and apoptosis publication-title: Fitoterapia doi: 10.1016/j.fitote.2015.08.014 – volume: 284 start-page: 15173 year: 2009 end-page: 15183 ident: CR66 article-title: Involvement of all- -retinal in acute light-induced retinopathy of mice publication-title: J Biol Chem doi: 10.1074/jbc.M900322200 – volume: 27 start-page: 1372 year: 2022 ident: CR65 article-title: A review of liposomes as a drug delivery system: current status of approved products, regulatory environments, and future perspectives publication-title: Molecules doi: 10.3390/molecules27041372 – volume: 34 start-page: 2173 year: 2022 end-page: 2185 ident: CR56 article-title: Phlorotannins-bioactivity and extraction perspectives publication-title: J Appl Phycol doi: 10.1007/s10811-022-02749-4 – volume: 15 year: 2021 ident: CR77 article-title: Glutamate: the master neurotransmitter and its implications in chronic stress and mood disorders publication-title: Front Hum Neurosci doi: 10.3389/fnhum.2021.722323 – volume: 36 start-page: 782 year: 2021 end-page: 788 ident: CR116 article-title: Dieckol alleviates dextran sulfate sodium-induced colitis via inhibition of inflammatory pathway and activation of Nrf2/HO-1 signaling pathway publication-title: Environ Toxicol doi: 10.1002/tox.23080 – volume: 11 start-page: 5 year: 2021 end-page: 13 ident: CR34 article-title: Natural products in cancer therapy: past, present and future publication-title: Nat Prod Bioprospect doi: 10.1007/s13659-020-00293-7 – ident: CR95 – volume: 34 start-page: 96 year: 2012 end-page: 105 ident: CR45 article-title: Neuroprotective effects of phlorotannins isolated from a brown alga, , against H O -induced oxidative stress in murine hippocampal HT22 cells publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2012.03.006 – volume: 287 start-page: 5059 year: 2012 end-page: 5069 ident: CR15 article-title: Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration publication-title: J Biol Chem doi: 10.1074/jbc.M111.315432 – volume: 138 start-page: 950 year: 2013 end-page: 955 ident: CR46 article-title: Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo publication-title: Food Chem doi: 10.1016/j.foodchem.2012.11.005 – volume: 141 start-page: 150 year: 2014 end-page: 159 ident: CR91 article-title: Existing and potential therapeutic uses for -acetylcysteine: the need for conversion to intracellular glutathione for antioxidant benefits publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2013.09.006 – volume: 23 start-page: 8468 year: 2022 ident: CR74 article-title: A review on the molecular mechanisms of action of natural products in preventing bone diseases publication-title: Int J Mol Sci doi: 10.3390/ijms23158468 – volume: 20 start-page: 1651 year: 2016 end-page: 1663 ident: CR19 article-title: Phloroglucinol protects retinal pigment epithelium and photoreceptor against all- -retinal-induced toxicity and inhibits A2E formation publication-title: J Cell Mol Med doi: 10.1111/jcmm.12857 – volume: 136 start-page: 355 year: 2015 end-page: 364 ident: CR110 article-title: Brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2014.11.015 – volume: 23 start-page: 1123 year: 2009 end-page: 1130 ident: CR31 article-title: Effect of phlorotannins isolated from on melanogenesis and their protective effect against photo-oxidative stress induced by UV-B radiation publication-title: Toxicol in Vitro doi: 10.1016/j.tiv.2009.05.013 – volume: 11 year: 2016 ident: CR54 article-title: Phlorofucofuroeckol improves glutamate-induced neurotoxicity through modulation of oxidative stress-mediated mitochondrial dysfunction in PC12 cells publication-title: PLoS ONE doi: 10.1371/journal.pone.0163433 – volume: 38 start-page: 1205 year: 2017 end-page: 1235 ident: CR16 article-title: Amyloid beta: structure, biology and structure-based therapeutic development publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2017.28 – volume: 36 start-page: 1931 year: 2016 end-page: 1942 ident: CR39 article-title: AMPK facilitates nuclear accumulation of Nrf2 by phosphorylating at Serine 550 publication-title: Mol Cell Biol doi: 10.1128/MCB.00118-16 – volume: 60 start-page: 5340 year: 2012 end-page: 5349 ident: CR60 article-title: Isolation and identification of phlorotannins from with antioxidant and hepatoprotective properties in tacrine-treated HepG2 cells publication-title: J Agric Food Chem doi: 10.1021/jf300157w – volume: 14 start-page: 583 year: 2020 end-page: 600 ident: CR115 article-title: Oxidative stress and diabetes: antioxidative strategies publication-title: Front Med doi: 10.1007/s11684-019-0729-1 – volume: 14 start-page: 581191 year: 2020 ident: CR108 article-title: Chemically induced models of Parkinson’s disease: history and perspectives for the involvement of ferroptosis publication-title: Front Cell Neurosci doi: 10.3389/fncel.2020.581191 – volume: 21 start-page: 239 year: 2012 end-page: 246 ident: CR62 article-title: Diphlorethohydroxycarmalol isolated from Pae ( ) protects high glucose-induced damage in RINm5F pancreatic β cells via its antioxidant effects publication-title: Food Sci Biotechnol doi: 10.1007/s10068-012-0031-3 – volume: 20 start-page: 8082 year: 2014 end-page: 8091 ident: CR20 article-title: Oxidative stress as a crucial factor in liver diseases publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i25.8082 – volume: 115 start-page: 1403 year: 2014 end-page: 1411 ident: CR52 article-title: Cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: involvement of the FoxO3a/AMPK pathway publication-title: J Cell Biochem doi: 10.1002/jcb.24790 – volume: 6 start-page: 235 year: 2016 ident: CR105 article-title: Antimicrobial, antioxidant, and anticancer activities of biosynthesized silver nanoparticles using marine algae publication-title: Nanomaterials doi: 10.3390/nano6120235 – volume: 5 start-page: 721 year: 2018 end-page: 733 ident: CR7 article-title: Nrf2-Keap1 signaling in oxidative and reductive stress publication-title: Biochim Biophys Acta Mol Cell Res doi: 10.1016/j.bbamcr.2018.02.010 – volume: 65 start-page: 645 year: 2013 end-page: 657 ident: CR96 article-title: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.07.022 – ident: CR76 – volume: 5 start-page: 2646 year: 2013 end-page: 2666 ident: CR87 article-title: Vitamin A derivatives as treatment options for retinal degenerative diseases publication-title: Nutrients doi: 10.3390/nu5072646 – volume: 10 year: 2015 ident: CR109 article-title: Phloroglucinol attenuates the cognitive deficits of the 5XFAD mouse model of Alzheimer's disease publication-title: PLoS ONE doi: 10.1371/journal.pone.0135686 – volume: 107 start-page: 1058 year: 2010 end-page: 1070 ident: CR28 article-title: Oxidative stress and diabetic complications publication-title: Circ Res doi: 10.1161/CIRCRESAHA.110.223545 – volume: 97 start-page: 609 year: 2006 end-page: 620 ident: CR43 article-title: Cytoprotective effect of phloroglucinol on oxidative stress induced cell damage via catalase activation publication-title: J Cell Biochem doi: 10.1002/jcb.20668 – volume: 16 start-page: 11779322221115436 year: 2022 ident: CR18 article-title: Phytochemical characterization, functional nutrition, and anti-diabetic potentials of (pers) Decne leaves: and studies publication-title: Bioinform Biol Insights doi: 10.1177/11779322221115436 – volume: 107 start-page: 1058 year: 2010 ident: 2913_CR28 publication-title: Circ Res doi: 10.1161/CIRCRESAHA.110.223545 – volume: 35 start-page: 1989 year: 2012 ident: 2913_CR2 publication-title: Arch Pharm Res doi: 10.1007/s12272-012-1116-5 – volume: 28 start-page: 322 year: 2012 ident: 2913_CR51 publication-title: Photodermatol Photoimmunol Photomed doi: 10.1111/phpp.12010 – volume: 23 start-page: 1123 year: 2009 ident: 2913_CR31 publication-title: Toxicol in Vitro doi: 10.1016/j.tiv.2009.05.013 – volume: 90 start-page: 592 year: 2012 ident: 2913_CR48 publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2012.05.082 – volume: 25 start-page: 3089 year: 2013 ident: 2913_CR69 publication-title: Plant Cell doi: 10.1105/tpc.113.111336 – volume: 30 start-page: 359 year: 2020 ident: 2913_CR72 publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.1910.10068 – volume: 60 start-page: 5340 year: 2012 ident: 2913_CR60 publication-title: J Agric Food Chem doi: 10.1021/jf300157w – volume: 8 year: 2013 ident: 2913_CR92 publication-title: PLoS ONE doi: 10.1371/journal.pone.0071178 – volume: 76 start-page: 1445 year: 2012 ident: 2913_CR61 publication-title: Biosci Biotechnol Biochem doi: 10.1271/bbb.120096 – volume: 34 start-page: 96 year: 2012 ident: 2913_CR45 publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2012.03.006 – volume: 97 start-page: 609 year: 2006 ident: 2913_CR43 publication-title: J Cell Biochem doi: 10.1002/jcb.20668 – volume: 27 start-page: 2049 year: 2015 ident: 2913_CR14 publication-title: J Appl Phycol doi: 10.1007/s10811-014-0476-2 – volume: 53 start-page: 174 year: 2018 ident: 2913_CR24 publication-title: Int J Food Sci Technol doi: 10.1111/ijfs.13571 – volume: 21 year: 2019 ident: 2913_CR99 publication-title: Food Packag Shelf Life doi: 10.1016/j.fpsl.2019.100346 – volume: 48 start-page: 1355 year: 2010 ident: 2913_CR32 publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2010.03.001 – ident: 2913_CR29 doi: 10.1101/2020.09.04.283473 – volume: 287 start-page: 5059 year: 2012 ident: 2913_CR15 publication-title: J Biol Chem doi: 10.1074/jbc.M111.315432 – volume: 16 start-page: 117793222211154 year: 2022 ident: 2913_CR18 publication-title: Bioinform Biol Insights doi: 10.1177/11779322221115436 – volume: 100 start-page: 14 year: 2016 ident: 2913_CR9 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2016.04.001 – ident: 2913_CR101 doi: 10.3390/ijms19123824 – volume: 579 start-page: 6295 year: 2005 ident: 2913_CR42 publication-title: FEBS Lett doi: 10.1016/j.febslet.2005.10.008 – volume: 36 start-page: 782 year: 2021 ident: 2913_CR116 publication-title: Environ Toxicol doi: 10.1002/tox.23080 – volume: 36 start-page: 1931 year: 2016 ident: 2913_CR39 publication-title: Mol Cell Biol doi: 10.1128/MCB.00118-16 – volume: 10 year: 2015 ident: 2913_CR109 publication-title: PLoS ONE doi: 10.1371/journal.pone.0135686 – volume: 15 start-page: 1051 year: 2021 ident: 2913_CR88 publication-title: J Tissue Eng Regen Med doi: 10.1002/term.3246 – volume: 66 start-page: 24 year: 2014 ident: 2913_CR26 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.05.045 – volume: 16 start-page: 1 year: 2013 ident: 2913_CR113 publication-title: Fish Aquatic Sci – volume: 91 start-page: 788 year: 2010 ident: 2913_CR84 publication-title: Exp Eye Res doi: 10.1016/j.exer.2010.08.013 – volume: 27 start-page: 809 year: 2010 ident: 2913_CR1 publication-title: Nat Prod Rep doi: 10.1039/b909988n – volume: 13 start-page: 528 year: 2019 ident: 2913_CR71 publication-title: Front Cell Neurosci doi: 10.3389/fncel.2019.00528 – volume: 14 start-page: 581191 year: 2020 ident: 2913_CR108 publication-title: Front Cell Neurosci doi: 10.3389/fncel.2020.581191 – volume: 34 start-page: 2173 year: 2022 ident: 2913_CR56 publication-title: J Appl Phycol doi: 10.1007/s10811-022-02749-4 – ident: 2913_CR57 doi: 10.1039/C4CC04270K – volume: 284 start-page: 15173 year: 2009 ident: 2913_CR66 publication-title: J Biol Chem doi: 10.1074/jbc.M900322200 – volume: 23 start-page: 121 year: 2019 ident: 2913_CR22 publication-title: Korean J Physiol Pharmacol doi: 10.4196/kjpp.2019.23.2.121 – volume: 2016 start-page: 7432797 year: 2016 ident: 2913_CR36 publication-title: Oxid Med Cell Longev doi: 10.1155/2016/7432797 – volume: 19 start-page: 219 year: 2015 ident: 2913_CR21 publication-title: Korean J Physiol Pharmacol doi: 10.4196/kjpp.2015.19.3.219 – ident: 2913_CR76 doi: 10.1177/1934578X211056144 – volume: 5 start-page: 721 year: 2018 ident: 2913_CR7 publication-title: Biochim Biophys Acta Mol Cell Res doi: 10.1016/j.bbamcr.2018.02.010 – volume: 4 year: 2022 ident: 2913_CR75 publication-title: Food Chem: Mol Sci – volume: 24 start-page: 325 year: 2015 ident: 2913_CR53 publication-title: Exp Neurobiol doi: 10.5607/en.2015.24.4.325 – volume: 15 year: 2021 ident: 2913_CR77 publication-title: Front Hum Neurosci doi: 10.3389/fnhum.2021.722323 – volume: 2018 start-page: 7857251 year: 2018 ident: 2913_CR67 publication-title: Oxid Med Cell Longev doi: 10.1155/2018/7857251 – volume: 34 start-page: 926 year: 2012 ident: 2913_CR38 publication-title: Environ Toxicol Pharmacol doi: 10.1016/j.etap.2012.08.003 – volume: 115 start-page: 1403 year: 2014 ident: 2913_CR52 publication-title: J Cell Biochem doi: 10.1002/jcb.24790 – volume: 11 start-page: 5 year: 2021 ident: 2913_CR34 publication-title: Nat Prod Bioprospect doi: 10.1007/s13659-020-00293-7 – volume: 138 start-page: 1764 year: 2013 ident: 2913_CR6 publication-title: Food Chem doi: 10.1016/j.foodchem.2012.11.026 – volume: 25 start-page: 4550 year: 2020 ident: 2913_CR5 publication-title: Molecules doi: 10.3390/molecules25194550 – volume: 33 start-page: 363 year: 2012 ident: 2913_CR78 publication-title: Mol Cells doi: 10.1007/s10059-012-2285-2 – volume: 115 start-page: 157 year: 2014 ident: 2913_CR58 publication-title: Prog Neurobiol doi: 10.1016/j.pneurobio.2013.11.006 – volume: 2017 start-page: 4076518 year: 2017 ident: 2913_CR73 publication-title: Oxid Med Cell Longev doi: 10.1155/2017/4076518 – volume: 32 start-page: 125 year: 2012 ident: 2913_CR93 publication-title: Annu Rev Nutr doi: 10.1146/annurev-nutr-071811-150748 – volume: 2020 start-page: 8878172 year: 2020 ident: 2913_CR85 publication-title: Oxid Med Cell Longev doi: 10.1155/2020/8878172 – volume: 2 start-page: 8 year: 2016 ident: 2913_CR90 publication-title: Int J Retin Vitr doi: 10.1186/s40942-016-0033-z – volume: 174 start-page: 632 year: 2014 ident: 2913_CR79 publication-title: Appl Biochem Biotechnol doi: 10.1007/s12010-014-1099-4 – volume: 29 start-page: 17 year: 2014 ident: 2913_CR3 publication-title: Reprod Biomed Online doi: 10.1016/j.rbmo.2014.03.002 – volume: 53 start-page: 294 year: 2013 ident: 2913_CR47 publication-title: Food Chem Toxicol doi: 10.1016/j.fct.2012.12.012 – volume: 14 start-page: 383 year: 2012 ident: 2913_CR50 publication-title: Mar Biotechnol (NY) doi: 10.1007/s10126-012-9459-y – volume: 23 start-page: 51 year: 2012 ident: 2913_CR12 publication-title: Vet Dermatol doi: 10.1111/j.1365-3164.2011.01009.x – volume: 2020 start-page: 8609213 year: 2020 ident: 2913_CR112 publication-title: Oxid Med Cell Longev doi: 10.1155/2020/8609213 – volume: 239 year: 2020 ident: 2913_CR23 publication-title: Carbohydr Polym doi: 10.1016/j.carbpol.2020.116214 – volume: 11 start-page: 1374 year: 2022 ident: 2913_CR103 publication-title: Antioxidants doi: 10.3390/antiox11071374 – volume: 68 start-page: 87 year: 2015 ident: 2913_CR10 publication-title: Adv Clin Chem doi: 10.1016/bs.acc.2014.11.001 – volume: 38 start-page: 1205 year: 2017 ident: 2913_CR16 publication-title: Acta Pharmacol Sin doi: 10.1038/aps.2017.28 – volume: 24 start-page: 375 year: 2010 ident: 2913_CR59 publication-title: Toxicol in Vitro doi: 10.1016/j.tiv.2009.11.002 – volume: 106 start-page: 135 year: 2015 ident: 2913_CR80 publication-title: Fitoterapia doi: 10.1016/j.fitote.2015.08.014 – volume: 43 start-page: 495 year: 2021 ident: 2913_CR17 publication-title: Int J Cosmet Sci doi: 10.1111/ics.12728 – volume: 9 start-page: 1349 year: 2018 ident: 2913_CR106 publication-title: ACS Chem Neurosci doi: 10.1021/acschemneuro.7b00527 – volume: 50 start-page: 939 year: 2016 ident: 2913_CR114 publication-title: Free Radic Res doi: 10.1080/10715762.2016.1209745 – volume: 2018 start-page: 3654095 year: 2018 ident: 2913_CR13 publication-title: Oxid Med Cell Longev doi: 10.1155/2018/3654095 – volume: 2019 start-page: 2105607 year: 2019 ident: 2913_CR11 publication-title: Oxid Med Cell Longev doi: 10.1155/2019/2105607 – volume: 2019 start-page: 9372182 year: 2019 ident: 2913_CR89 publication-title: Oxid Med Cell Longev doi: 10.1155/2019/9372182 – volume: 17 start-page: 225 year: 2019 ident: 2913_CR82 publication-title: Mar Drugs doi: 10.3390/md17040225 – ident: 2913_CR95 doi: 10.1007/s00210-019-01652-z – volume: 166 start-page: 1520 year: 2012 ident: 2913_CR33 publication-title: Appl Biochem Biotechnol doi: 10.1007/s12010-012-9545-7 – volume: 15 start-page: 561 year: 2014 ident: 2913_CR55 publication-title: Asian Pac J Cancer Prev doi: 10.7314/APJCP.2014.15.2.561 – volume: 996 start-page: 15 year: 2017 ident: 2913_CR25 publication-title: Adv Exp Med Biol doi: 10.1007/978-3-319-56017-5_2 – volume: 2018 start-page: 1 year: 2018 ident: 2913_CR63 publication-title: Evid Based Complement Alternat Med doi: 10.1155/2018/7635197 – volume: 16 start-page: 300 year: 2018 ident: 2913_CR64 publication-title: Mar Drugs doi: 10.3390/md16090300 – volume: 581 start-page: 2000 year: 2007 ident: 2913_CR44 publication-title: FEBS Lett doi: 10.1016/j.febslet.2007.04.022 – volume: 136 start-page: 355 year: 2015 ident: 2913_CR110 publication-title: Gynecol Oncol doi: 10.1016/j.ygyno.2014.11.015 – volume: 5 start-page: 2646 year: 2013 ident: 2913_CR87 publication-title: Nutrients doi: 10.3390/nu5072646 – volume: 31 start-page: 584 year: 2021 ident: 2913_CR98 publication-title: J Microbiol Biotechnol doi: 10.4014/jmb.2012.12013 – volume: 2010 year: 2010 ident: 2913_CR41 publication-title: Mediators Inflamm doi: 10.1155/2010/453892 – volume: 8 start-page: 569 year: 2019 ident: 2913_CR107 publication-title: Antioxidants doi: 10.3390/antiox8120569 – volume: 27 start-page: 1372 year: 2022 ident: 2913_CR65 publication-title: Molecules doi: 10.3390/molecules27041372 – volume: 44 start-page: 263 year: 2018 ident: 2913_CR37 publication-title: Russ J Mar Biol doi: 10.1134/S106307401804003X – volume: 20 start-page: 387 year: 2022 ident: 2913_CR70 publication-title: Mar Drugs doi: 10.3390/md20060387 – volume: 21 start-page: 239 year: 2012 ident: 2913_CR62 publication-title: Food Sci Biotechnol doi: 10.1007/s10068-012-0031-3 – volume: 6 start-page: 235 year: 2016 ident: 2913_CR105 publication-title: Nanomaterials doi: 10.3390/nano6120235 – volume: 15 start-page: 162 year: 2011 ident: 2913_CR35 publication-title: Curr Opin Chem Biol doi: 10.1016/j.cbpa.2010.12.009 – volume: 20 start-page: 243 year: 2022 ident: 2913_CR8 publication-title: Mar Drugs doi: 10.3390/md20040243 – volume: 24 start-page: 547 year: 2016 ident: 2913_CR4 publication-title: Saudi Pharm J doi: 10.1016/j.jsps.2015.03.013 – volume: 257 start-page: 128 year: 2018 ident: 2913_CR81 publication-title: Food Chem doi: 10.1016/j.foodchem.2018.03.013 – volume: 138 start-page: 950 year: 2013 ident: 2913_CR46 publication-title: Food Chem doi: 10.1016/j.foodchem.2012.11.005 – volume: 60 year: 2021 ident: 2913_CR68 publication-title: Algal Res doi: 10.1016/j.algal.2021.102484 – volume: 11 start-page: 1312 year: 2022 ident: 2913_CR104 publication-title: Cells doi: 10.3390/cells11081312 – volume: 84 start-page: 1810 year: 2016 ident: 2913_CR94 publication-title: Biomed Pharmacother doi: 10.1016/j.biopha.2016.10.091 – volume: 65 start-page: 645 year: 2013 ident: 2913_CR96 publication-title: Free Radic Biol Med doi: 10.1016/j.freeradbiomed.2013.07.022 – volume: 12 start-page: 332 year: 2020 ident: 2913_CR100 publication-title: World J Hepatol doi: 10.4254/wjh.v12.i7.332 – volume: 141 start-page: 150 year: 2014 ident: 2913_CR91 publication-title: Pharmacol Ther doi: 10.1016/j.pharmthera.2013.09.006 – volume: 20 start-page: 8082 year: 2014 ident: 2913_CR20 publication-title: World J Gastroenterol doi: 10.3748/wjg.v20.i25.8082 – volume: 11 year: 2016 ident: 2913_CR54 publication-title: PLoS ONE doi: 10.1371/journal.pone.0163433 – volume: 14 start-page: 583 year: 2020 ident: 2913_CR115 publication-title: Front Med doi: 10.1007/s11684-019-0729-1 – volume: 38 start-page: 298 year: 2019 ident: 2913_CR83 publication-title: Cutan Ocul Toxicol doi: 10.1080/15569527.2019.1613425 – volume: 51 start-page: 35 year: 2013 ident: 2913_CR30 publication-title: Neurobiol Dis doi: 10.1016/j.nbd.2012.10.011 – volume: 23 start-page: 8468 year: 2022 ident: 2913_CR74 publication-title: Int J Mol Sci doi: 10.3390/ijms23158468 – volume: 42 start-page: 297 year: 2010 ident: 2913_CR49 publication-title: Int J Biochem Cell Biol doi: 10.1016/j.biocel.2009.11.009 – ident: 2913_CR111 doi: 10.1016/j.jphs.2021.01.008 – volume: 20 start-page: 705 year: 2008 ident: 2913_CR97 publication-title: J Appl Phycol doi: 10.1007/s10811-007-9254-8 – volume: 19 start-page: 625 year: 2021 ident: 2913_CR102 publication-title: Mar Drugs doi: 10.3390/md19110625 – volume: 20 start-page: 1651 year: 2016 ident: 2913_CR19 publication-title: J Cell Mol Med doi: 10.1111/jcmm.12857 – ident: 2913_CR27 doi: 10.1038/s41573-021-00233-1 – volume: 52 start-page: 192 year: 2020 ident: 2913_CR86 publication-title: Exp Mol Med doi: 10.1038/s12276-020-0384-2 – volume: 19 start-page: 15638 year: 2014 ident: 2913_CR40 publication-title: Molecules doi: 10.3390/molecules191015638
SSID	ssj0009818
Score	2.5003679
SecondaryResourceType	review_article
Snippet	Phlorotannins are polyphenolic compounds that are exclusively derived from marine brown algae. The molecular structure of phlorotannins with numerous phenol...
SourceID	proquest crossref springer
SourceType	Aggregation Database Enrichment Source Index Database Publisher
StartPage	867
SubjectTerms	Algae antioxidant activity Antioxidant properties Antioxidants Bioavailability Biocompatibility Biomedical and Life Sciences chemical structure Defence mechanisms diabetes Diabetes mellitus Diseases Drug carriers Drug delivery drugs Ecology Encapsulation Freshwater & Marine Ecology In vivo methods and tests Life Sciences Liver diseases Molecular structure Nanofibers Nanoparticles Neurodegenerative diseases Oxidation Oxidative stress Pathogenesis Phaeophyceae phenol Phenols phlorotannins Plant Physiology Plant Sciences Polyphenols Reactive oxygen species Scavenging Skin diseases therapeutics
SummonAdditionalLinks	– databaseName: ProQuest Central dbid: BENPR link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dS9xAEB_qF7QPpZ6WXrVlhb7p4mWz2dv1pWhRpKCIVPAt7NfpQU2sOaE-9V_vTLJnqlCfQpJJlmRmZ-djfzMAX-xITXweBQ9GWS7RwEc9aMdcKm9zH8klIbzzyak6vpDfL4vLFHBr0rbKuU5sFXWoPcXId8XY4NIulFZfb39x6hpF2dXUQmMBllAFa5TwpYPD07PzvuyubiN8IyMyrs04S7CZBJ7TFB4UlMc0Wc7l06WptzefpUjblefoHbxNJiPb73i8Cq9iNYA3-1d3qWxGHMBK11LyYQDLBzWaew9r8OfsGl1xOqmmVcMIRsIc-dyM0Btxj1nWwVZYXbE2XcAs7Xz8PQ14ZDeRIMHT5qbBy4H9m-dm04q1ZKQpWQc24S0CBa1XljI-zTpcHB3--HbMU7cF7tEIm3EfCkelodA_c947L4XI8uiCDUa4IjhBKFtKI3pZyNz70UShbSKNcoV0Oor8PSxWdRU_AMukiCL4kEc_ka4wxgmbZ1YFp3XUQQwhm__o0qdS5NQR42fZF1Em5pTInLJlTimHsP34zG1XiONF6s05_8o0KZuyF6EhbD3exulEORJbxfoeafCLUFCUQZqdOd_7V_x_xI8vj7gBr0UrarTnZxMWZ3f38ROaMzP3OcnsX80B8gI priority: 102 providerName: ProQuest
Title	Phlorotannins from brown algae: a review on their antioxidant mechanisms and applications in oxidative stress-mediated diseases
URI	https://link.springer.com/article/10.1007/s10811-023-02913-4 https://www.proquest.com/docview/2791432686 https://www.proquest.com/docview/2849897696
Volume	35
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3da9swED_WL9geypa2LFtbNNjbKohlWbH2lrTJysZKGQu0T0ZfaQOtM-oU1qf967uT7aYd3WBPMvJZxr6T9DudfieA96anpi4NgnutDJcI8HEcNH0ulTOpC-SSEN_564k6nsjPZ9lZQwqr2t3ubUgyjtQPyG45LecJijvqJOVyBdYy9N3JridisEy1m8dVvZ4WCc91P2moMk-38Xg6WmLMP8KicbYZv4TNBiayQa3XV_AslB14Mbi4aVJlhA5s1MdI3nVgfThHiIcXG6OYg_puC36dXqIjTtXlrKwYkUiYJY-bEXcjfGSG1aQVNi9ZDBYwQ_sef848luw6ECF4Vl1XWO3Zwyg3m5UsitE4yWqqCY_8E8SurIn3VNswGY--Hx7z5qwF7hCCLbjzmaXEUOidWeesk0IkabDeeC1s5q0gji0FEZ3MZOpcb6oQmUitbCZtHkS6A6vlvAyvgSVSBOGdT4ObSptpbYVJE6O8zfOQe9GFpP3lhWsSkdN5GFfFMoUyqalANRVRTYXswof7Z37UaTj-Kb3barJoumRViL5GbChUrrrw7v42diaKkJgyzG9RBr8ITUZplDloLWDZxN_f-Ob_xN_CcxGNkHYA7cLq4uY27CG4Wdh9WBsMj4ZjKj-dfxlhORydnH7bjzb-G6j79PM
linkProvider	Springer Nature
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3dT9RAEJ-QQ6M8GD0lHKKuiT7pxut2u9c1MQYUcghciIGEt7pfp5dIi_SI3pP_kX-jM_2gaiJvPDVtp920MzsfO_ubAXhmhmrq4iC418pwiQ4-6kEz4lI5E7tAIQnhnQ8manwsP5wkJ0vwq8XC0LbKVidWitoXjtbIX4mRRtMuVKrenn3j1DWKsqttC41aLPbC4juGbOWb3ffI3-dC7GwfvRvzpqsAd-hszLnziaUSSBiHWOesk0JEcbDeeC1s4q0gNCmly5xMZOzccKrQBkutbCJtGqjQAar8ZRmjq9CD5a3tyeHHrsxvWq0oDrWIeKpHUQPTacB6KS1HCsqb6ijm8m9T2Pm3_6RkK0u3cxfuNC4q26xl6h4shbwPK5ufz5syHaEPN-sWlos-3Ngq0L1c3Iefh18w9KeTfJaXjGArzFKMzwgtEl4zw2qYDCtyVqUnmKGdlj9mHo_sNBAEeVaelnjZsz_z6myWs4qMNDOrwS28Qrygt8yaDFP5AI6vhQ-r0MuLPKwBi6QIwjsfBzeVNtHaChNHRnmbpiH1YgBR-6Mz15Q-pw4cX7OuaDMxJ0PmZBVzMjmAF5fPnNWFP66k3mj5lzVKoMw6kR3A08vbOH0pJ2PyUFwgDX4RCorSSPOy5Xv3iv-PuH71iE_g1vjoYD_b353sPYTbohI72m-0Ab35-UV4hK7U3D5u5JfBp-ueMr8BDDouHA
linkToPdf	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1fb9NADLemDhA8ICggCgMOCZ7gtOZyuSZICG1s1cagqhCT9hbuX6HSloymE_SJ78Wnw04uCyCxtz1FSZycEvt89tk_G-CZHqqZjb3gLlOaSzTwUQ_qEZfK6th6ckkI7_xhovYO5buj5GgNfrVYGEqrbHVirahdaWmPfFOMMlzahUrV5iykRUx3xm9Ov3HqIEWR1radRiMiB371Hd236vX-DvL6uRDj3U9v93joMMAtGh5Lbl1iqBwS-iTGWmOlEFHsjdMuEyZxRhCylEJnViYytnY4U7gey0yZRJrUU9EDVP_rI4KP9mB9e3cy_diV_E3r3cVhJiKeZqMoQHYCcC-lrUlBMdQsirn8e1nsbN1_wrP1qje-BTeDucq2Gvm6DWu-6MONrS-LULLD9-Fq085y1Ycr2yWamqs78HP69bhc0EkxLypGEBZmyN9nhBzxr5hmDWSGlQWrQxVMU9blj7nDIzvxBEeeVycVXnbszxg7mxesJiMtzRqgC6_RL2g5sxBtqu7C4aXw4R70irLw94FFUnjhrIu9nUmTZJkROo60ciZNferEAKL2R-c2lEGnbhzHeVfAmZiTI3Pymjm5HMCL82dOmyIgF1JvtPzLg0Ko8k58B_D0_DZOZYrP6MKXZ0iDX4SCojKkednyvXvF_0d8cPGIT-AaTpX8_f7k4CFcF7XUUerRBvSWizP_CK2qpXkcxJfB58ueMb8BRb4yWg
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Phlorotannins+from+brown+algae%3A+a+review+on+their+antioxidant+mechanisms+and+applications+in+oxidative+stress-mediated+diseases&rft.jtitle=Journal+of+applied+phycology&rft.au=Phang%2C+Shou+Jin&rft.au=Teh%2C+Huey+Xhin&rft.au=Looi%2C+Mee+Lee&rft.au=Arumugam%2C+Bavani&rft.date=2023-04-01&rft.pub=Springer+Netherlands&rft.issn=0921-8971&rft.eissn=1573-5176&rft.volume=35&rft.issue=2&rft.spage=867&rft.epage=892&rft_id=info:doi/10.1007%2Fs10811-023-02913-4&rft.externalDocID=10_1007_s10811_023_02913_4
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0921-8971&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0921-8971&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0921-8971&client=summon