3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate induced Hep G2 cell apoptosis through a ROS-mediated pathway

• Published in: Chemico-biological interactions Vol. 183; no. 3; pp. 341 - 348
• Main Authors: Li, Jianyong, Xu, Zhijun, Tan, Mengyao, Su, Weike, Gong, Xing-guo
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 12.02.2010
• Subjects: Apoptosis; Benzothiazole; Benzothiazoles - chemistry; Benzothiazoles - toxicity; Caspase; Caspase 9 - metabolism; DPB-5; Drug Screening Assays, Antitumor; Glutathione - metabolism; Hep G2 Cells; Humans; Membrane Potential, Mitochondrial - drug effects; Pyrazoles - chemistry; Pyrazoles - toxicity; Reactive Oxygen Species - metabolism; ROS; Benzothiazole; Caspase; MTT; Rh123; MMP; DCFH-DA; NAC; AMBAN; ROT; ROS; CAT; PI; DPB-5; GSH; Apoptosis

3-(4-(Benzo[d]thiazol-2-yl)-1-phenyl-1H-pyrazol-3-yl) phenyl acetate (DPB-5) is a synthetic benzothiazole derivative. In the present study, we revealed that DPB-5 had strong cytotoxicity to induce cell apoptosis, which was mediated by ROS. And DPB-5 was more cytotoxic toward hepatoma cells than towa...