Sodium Butyrate Exacerbates Parkinson’s Disease by Aggravating Neuroinflammation and Colonic Inflammation in MPTP-Induced Mice Model

• Published in: Neurochemical research Vol. 45; no. 9; pp. 2128 - 2142
• Main Authors: Qiao, Chen-Meng, Sun, Meng-Fei, Jia, Xue-Bing, Li, Yang, Zhang, Bo-Ping, Zhao, Li-Ping, Shi, Yun, Zhou, Zhi-Lan, Zhu, Ying-Li, Cui, Chun, Shen, Yan-Qin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2020; Springer Nature B.V
• Subjects: Astrocytes; Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell Biology; Colon; Cytokines; Dopamine; Dopamine receptors; Dysbacteriosis; Fatty acids; Hydroxylase; IL-1β; Inflammation; Interleukin 18; Interleukin 6; Intestinal microflora; Lipopolysaccharides; Microglia; Microorganisms; Movement disorders; MPTP; MyD88 protein; Neurochemistry; Neurodegenerative diseases; Neurology; Neuronal-glial interactions; Neurosciences; NF-κB protein; Nitric-oxide synthase; Original Paper; Parkinson's disease; Pathogenesis; Signal transduction; Sodium; Sodium butyrate; Tumor necrosis factor-α; Tyrosine; Tyrosine 3-monooxygenase; Sodium butyrate; Parkinson’s disease (PD); Neuroinflammation; MPTP; Colonic inflammation

The abnormal production of short chain fatty acid (SCFAs) caused by gut microbial dysbiosis plays an important role in the pathogenesis and progression of Parkinson’s disease (PD). This study sought to evaluate how butyrate, one of SCFAs, affect the pathology in a subacute 1-methyl-4-phenyl-1,2,3,6-...