Effects of phenylbutazone on gene expression of cyclooxygenase-1 and -2 in the oral, glandular gastric, and bladder mucosae of healthy horses

• Published in: American journal of veterinary research Vol. 73; no. 1; pp. 98 - 104
• Main Authors: Nieto, Jorge E, Aleman, Monica, Anderson, Jonathan D, Fiack, Ciara, Snyder, Jack R
• Format: Journal Article
• Language: English
• Published: United States 2012
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - pharmacology; biopsy; bladder; corn syrup; Cyclooxygenase 1 - genetics; Cyclooxygenase 2 - genetics; Cystoscopy - veterinary; endoscopy; Female; Gastroscopy - veterinary; gene expression; Gene Expression Regulation - drug effects; genes; horses; Horses - metabolism; Male; Mouth - drug effects; Mouth - pathology; mucosa; Mucous Membrane - drug effects; Mucous Membrane - pathology; oral administration; phenylbutazone; Phenylbutazone - administration & dosage; Phenylbutazone - pharmacology; placebos; Polymerase Chain Reaction - veterinary; prostaglandin synthase; quantitative polymerase chain reaction; RNA, Messenger - metabolism; stomach; Stomach - drug effects; Stomach - pathology; Urinary Bladder - drug effects; Urinary Bladder - pathology

Objective-To assess gene expressions of cyclooxygenase-1 and -2 in oral, glandular gastric, and urinary bladder mucosae and determine the effect of oral administration of phenylbutazone on those gene expressions in horses. Animals-12 healthy horses. Procedures-Horses were allocated to receive phenyl...