Naloxone Diminishes the Virulence and Modifies the Cellular Immune Responses of BALB/c Mice Infected with Leishmania major

• Published in: Acta parasitologica Vol. 66; no. 2; pp. 517 - 523
• Main Authors: Alimohammadian, Mohammad Hossein, Riazi-Rad, Farhad, Asadi-Tat, Mahsa, Darabi, Sima, Darabi, Haiedeh, Khaze, Vahid, Bahrami, Fariborz, Ajdary, Soheila
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2021; Springer Nature B.V
• Subjects: Animal Systematics/Taxonomy/Biogeography; Biomedical and Life Sciences; Biomedicine; Cell proliferation; Cytokines; Ecology; Immune response; Immune response (cell-mediated); Immune system; Infections; Interleukin 10; Interleukin 12; Interleukin 4; Leishmania major; Lesions; Lymphocytes T; Medical Microbiology; Microbiology; Naloxone; Original Paper; Parasites; Parasitology; Rodents; Virulence; γ-Interferon; Cutaneous leishmaniasis; BALB/c mice; Naloxone

Purpose Leishmania major -infected BALB/c mice display strong susceptibility to the infection due to the induction of Th2 response. The aim of this study was to assess the effects of naloxone on virulence of L. major in BALB/c mice and the ensued cellular immune response. Methods The effects of inje...