Advancing lipid nanoparticles: A pioneering technology in cosmetic and dermatological treatments

Lipid nanoparticles (LNPs) represent a groundbreaking advancement in the realms of cosmetics and dermatology, providing advantages over traditional formulations. This paper explores the revolutionary potential of LNPs, particularly Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (...

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Published inColloid and interface science communications Vol. 64; p. 100814
Main Authors Pareek, Anil, Kapoor, Devesh U., Yadav, Sandeep Kumar, Rashid, Summya, Fareed, Mohammad, Akhter, Mohammad Suhail, Muteeb, Ghazala, Gupta, Madan Mohan, Prajapati, Bhupendra G.
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.01.2025
Subjects
Cosmetics
Dermatology
Drug delivery systems
Lipid nanoparticles
Nanotechnology
Skin disorders
Cosmetics
Drug delivery systems
Dermatology
Lipid nanoparticles
Nanotechnology
Skin disorders
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Abstract Lipid nanoparticles (LNPs) represent a groundbreaking advancement in the realms of cosmetics and dermatology, providing advantages over traditional formulations. This paper explores the revolutionary potential of LNPs, particularly Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), in enhancing cosmetic and dermatological applications. The review highlights the advantages of LNPs, including improved skin penetration, improved bioavailability and controlled release of active ingredients, which together contribute to their superior performance compared to conventional formulations. Notable applications discussed include their roles in acne treatment, anti-aging solutions, wound healing, skin-lightening products, and sunscreens. This study examines the structural features and formulation techniques of LNPs, highlighting biocompatibility, and targeted delivery capabilities. We also explore emerging uses such as genetic medicine and mRNA vaccine delivery, alongside market trends and consumer acceptance. By summarizing recent developments and identifying existing challenges, this paper offers a thorough overview of LNPs for future research in pharmaceutical and cosmetic advancements. [Display omitted] •Lipid nanoparticles penetrate the skin through transcellular, intercellular and follicular penetration.•LNPs showed escalated skin penetration, enhanced bioavailability with controlled release profiles.•LNPs are useful in treating infectious as well as inflammatory skin disease.•LNPs showed significant effect in cosmeceuticals such as anti-aging, Skin brightening, Sunscreen.
AbstractList Lipid nanoparticles (LNPs) represent a groundbreaking advancement in the realms of cosmetics and dermatology, providing advantages over traditional formulations. This paper explores the revolutionary potential of LNPs, particularly Solid Lipid Nanoparticles (SLNs) and Nanostructured Lipid Carriers (NLCs), in enhancing cosmetic and dermatological applications. The review highlights the advantages of LNPs, including improved skin penetration, improved bioavailability and controlled release of active ingredients, which together contribute to their superior performance compared to conventional formulations. Notable applications discussed include their roles in acne treatment, anti-aging solutions, wound healing, skin-lightening products, and sunscreens. This study examines the structural features and formulation techniques of LNPs, highlighting biocompatibility, and targeted delivery capabilities. We also explore emerging uses such as genetic medicine and mRNA vaccine delivery, alongside market trends and consumer acceptance. By summarizing recent developments and identifying existing challenges, this paper offers a thorough overview of LNPs for future research in pharmaceutical and cosmetic advancements. [Display omitted] •Lipid nanoparticles penetrate the skin through transcellular, intercellular and follicular penetration.•LNPs showed escalated skin penetration, enhanced bioavailability with controlled release profiles.•LNPs are useful in treating infectious as well as inflammatory skin disease.•LNPs showed significant effect in cosmeceuticals such as anti-aging, Skin brightening, Sunscreen.
ArticleNumber 100814
Author Gupta, Madan Mohan
Yadav, Sandeep Kumar
Prajapati, Bhupendra G.
Kapoor, Devesh U.
Akhter, Mohammad Suhail
Pareek, Anil
Muteeb, Ghazala
Fareed, Mohammad
Rashid, Summya
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  givenname: Anil
  surname: Pareek
  fullname: Pareek, Anil
  organization: Department of Pharmaceutics, Lachoo Memorial College of Science and Technology (Autonomous), Jodhpur, Rajasthan 342001, India
– sequence: 2
  givenname: Devesh U.
  surname: Kapoor
  fullname: Kapoor, Devesh U.
  email: dev7200@gmail.com
  organization: Dr. Dayaram Patel Pharmacy College, Bardoli 394601, Gujarat, India
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  givenname: Sandeep Kumar
  surname: Yadav
  fullname: Yadav, Sandeep Kumar
  organization: Department of Pharmacology, SGT College of Pharmacy, Shree Guru Gobind Singh Tricentenary (SGT) University, Gurugram, Haryana 122505, India
– sequence: 4
  givenname: Summya
  surname: Rashid
  fullname: Rashid, Summya
  organization: Department of Pharmacology & Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia
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  givenname: Mohammad
  surname: Fareed
  fullname: Fareed, Mohammad
  organization: Department of Basic Medical Sciences, College of Medicine, AlMaarefa University, P.O. Box 71666, Riyadh 13713, Saudi Arabia
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  givenname: Mohammad Suhail
  surname: Akhter
  fullname: Akhter, Mohammad Suhail
  organization: MLT Department, College of Nursing and Health Sciences, Jazan University, Jizan, Saudi Arabia
– sequence: 7
  givenname: Ghazala
  surname: Muteeb
  fullname: Muteeb, Ghazala
  organization: Department of Nursing, College of Applied Medical Sciences, King Faisal University, Al-Ahsa 31982, Saudi Arabia
– sequence: 8
  givenname: Madan Mohan
  surname: Gupta
  fullname: Gupta, Madan Mohan
  organization: NIMS Institute of Pharmacy, NIMS University Rajasthan, Jaipur, India
– sequence: 9
  givenname: Bhupendra G.
  surname: Prajapati
  fullname: Prajapati, Bhupendra G.
  email: bhupen27@gmail.com
  organization: Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva 384012, Gujarat, India
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Keywords Cosmetics
Drug delivery systems
Dermatology
Lipid nanoparticles
Nanotechnology
Skin disorders
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Snippet Lipid nanoparticles (LNPs) represent a groundbreaking advancement in the realms of cosmetics and dermatology, providing advantages over traditional...
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SubjectTerms Cosmetics
Dermatology
Drug delivery systems
Lipid nanoparticles
Nanotechnology
Skin disorders
Title Advancing lipid nanoparticles: A pioneering technology in cosmetic and dermatological treatments
URI https://dx.doi.org/10.1016/j.colcom.2024.100814
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