Catalytic oxidative dehydrogenation of malic acid to oxaloacetic acid

• Published in: Green chemistry : an international journal and green chemistry resource : GC Vol. 21; no. 17; pp. 464 - 468
• Main Authors: Drif, Asmaa, Pineda, Antonio, Morvan, Didier, Belliere-Baca, Virginie, De Oliveira Vigier, Karine, Jérôme, François
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 27.08.2019; Royal Society of Chemistry
• Subjects: Amino acids; Catalysis; Catalysts; Chemical Sciences; Chemistry; Chemistry, Multidisciplinary; Decarboxylation; Dehydrogenation; Fabrication; Green & Sustainable Science & Technology; Green chemistry; Malic acid; Oxaloacetic acid; Oxidation; Physical Sciences; Pyruvic acid; Science & Technology; Science & Technology - Other Topics; ALCOHOLS; MALEIC-ANHYDRIDE; SELECTIVE OXIDATION; CONVERSION; KINETICS; GLUCOSE; DECARBOXYLATION; ISOSORBIDE; MOLECULAR-OXYGEN
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/c9gc01768b

Here we report the oxidative dehydrogenation of malic acid to oxaloacetic acid, a key precursor in the fabrication of amino acids, over Pt-Bi/C catalysts. Under optimized conditions, we discovered that OAA was selectively produced with up to 60% conversion ( i.e. 60% yield). The recurrent unwanted decarboxylation of OAA to pyruvic acid was circumvented by successfully conducting the catalytic reaction at 25 °C. A comparison with the classical Fenton oxidation reaction is discussed. Here we report the oxidative dehydrogenation of malic acid to oxaloacetic acid, a key precursor in the fabrication of amino acids, over Pt-Bi/C catalysts.