Effect of sodium concentration on aldosterone secretion by isolated perfused canine adrenal glands

• Published in: Endocrinology (Philadelphia) Vol. 115; no. 6; p. 2195
• Main Authors: Schneider, E G, Taylor, Jr, R E, Radke, K J, Davis, P G
• Format: Journal Article
• Language: English
• Published: United States 01.12.1984
• Subjects: Adrenal Glands - secretion; Aldosterone - secretion; Angiotensin II - pharmacology; Animals; Dogs; Female; In Vitro Techniques; Osmolar Concentration; Perfusion - instrumentation; Potassium - pharmacology; Sodium - pharmacology; Stimulation, Chemical; Time Factors

Small changes in sodium concentration [( Na]) are not generally considered to have a major direct effect on aldosterone secretion. However, a marked disruption in the renin-aldosterone relationship has been observed in a variety of hypernatremic and hyponatremic states. Therefore, we evaluated the h...