Enhancing transduction efficiency of adeno-associated virus 9 by cell line engineering: implication for gene therapy potency assay

• Published in: Biotechnology and bioprocess engineering Vol. 29; no. 2; pp. 405 - 411
• Main Authors: Go, Nanyeong, Ahn, Changhyun, Lee, Jae Young
• Format: Journal Article
• Language: English
• Published: Seoul The Korean Society for Biotechnology and Bioengineering 01.04.2024; Springer Nature B.V
• Subjects: Assaying; Biotechnology; Blood-brain barrier; Cell lines; Chemistry; Chemistry and Materials Science; Dependoparvovirus; Gene expression; Gene therapy; genes; humans; Industrial and Production Engineering; Infectivity; Neurological diseases; pathogenicity; Research Paper; Serotypes; Transduction; Adeno-associated virus; G protein-coupled receptor 108; Adeno-associated virus receptor; Potency assay

Adeno-associated virus (AAV)-mediated gene therapy holds significant promises to treat or potentially cure various human diseases. Although AAV holds promise for their significant therapeutic potential, batch-to-batch differences can exist from manufacturing; and therefore, a potency assay is requir...