The activity and expression of NTPDase is altered in lymphocytes of multiple sclerosis patients

• Published in: Clinica chimica acta Vol. 411; no. 3; pp. 210 - 214
• Main Authors: Spanevello, Roselia M., Mazzanti, Cinthia M., Schmatz, Roberta, Thomé, Gustavo, Bagatini, Margarete, Correa, Maisa, Rosa, Cintia, Stefanello, Naiara, Bellé, Luziane Potrich, Moretto, Maria B., Oliveira, Liliane, Morsch, Vera M., Schetinger, Maria R.C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.02.2010
• Subjects: Adenosine deaminase; Adenosine Deaminase - metabolism; Adenosine Diphosphate - metabolism; Adenosine Triphosphate - metabolism; Adult; Aged; Antigens, CD - metabolism; Apyrase - metabolism; Case-Control Studies; Female; Gene Expression Regulation, Enzymologic; Humans; Lymphocytes; Lymphocytes - metabolism; Male; Middle Aged; Multiple sclerosis; Multiple Sclerosis - enzymology; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; NTPDase; Recurrence; Multiple sclerosis; Adenosine deaminase; Lymphocytes; NTPDase

Multiple sclerosis (MS) is a demyelinating neurological disease, which is presumed to be a consequence of infiltrating lymphocytes that are autoreactive to myelin proteins. ATP and adenosine contribute to fine-tuning immune responses and NTPDase (CD39) and adenosine deaminase (ADA) are important enz...