Alteration of autoantibodies against p53 in Taiwanese lung cancer patients undergoing chemotherapy

Correlation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been investigated. Our present study aimed at evaluating putative possibility of using p53 Abs levels as a model system to monitor effect of chemotherapy and p...

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Published inClinica chimica acta Vol. 349; no. 1; pp. 87 - 96
Main Authors Lee, Yao-Ling, Shih, Chuen-Ming, Chiou, Hui-Ling, Shiau, Ming-Yuh, Chang, Gee-Chen, Chang, Yih-Hsin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2004
Subjects
Adult
Aged
Aged, 80 and over
Anti-p53 autoantibodies
Antineoplastic Agents - therapeutic use
Autoantibodies - analysis
Blotting, Western
Chemotherapy
DNA, Complementary - biosynthesis
DNA, Complementary - genetics
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lung cancer
Lung Neoplasms - blood
Lung Neoplasms - drug therapy
Lung Neoplasms - immunology
Male
Middle Aged
Prognosis
Taiwan
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - chemistry
Tumor Suppressor Protein p53 - immunology
Taiwan
ACC
SCLC
PR
NSCLC
Lung cancer
C/T
p53 Abs
LCC
SCC
Chemotherapy
PD
R/T
Anti-p53 autoantibodies
Ca
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Abstract Correlation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been investigated. Our present study aimed at evaluating putative possibility of using p53 Abs levels as a model system to monitor effect of chemotherapy and prognosis prediction of lung cancer. The prevalence of p53 Abs in lung cancer patients and temporal alteration of p53 Abs titers in lung cancer patients carrying p53 Abs were investigated by using ELISA and Western blot analysis. p53 Abs was detected in 17 of 277 (6.14%) lung cancer patients, the positivity of p53 Abs in patients with small cell lung carcinoma and non-small cell lung carcinoma was 4.88% and 6.36%, respectively. No significant association between p53 Abs and patients' clinical manifestations was found. Titer of p53 Abs was decreased in 6 of 17 p53 Abs-carrying patients after chemotherapy. However, the decreasing p53 Abs titers were not correlated with patients' survival or chemotherapeutic efficacy. The prevalence of p53 Abs in Taiwanese lung cancer is much lower than that in Caucasians. It is unlikely that p53 Abs titer could be a monitoring indicator for the chemotherapeutic efficacy or a prognosis indicator of lung cancer.
AbstractList BACKGROUNDCorrelation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been investigated. Our present study aimed at evaluating putative possibility of using p53 Abs levels as a model system to monitor effect of chemotherapy and prognosis prediction of lung cancer.METHODSThe prevalence of p53 Abs in lung cancer patients and temporal alteration of p53 Abs titers in lung cancer patients carrying p53 Abs were investigated by using ELISA and Western blot analysis.RESULTSp53 Abs was detected in 17 of 277 (6.14%) lung cancer patients, the positivity of p53 Abs in patients with small cell lung carcinoma and non-small cell lung carcinoma was 4.88% and 6.36%, respectively. No significant association between p53 Abs and patients' clinical manifestations was found. Titer of p53 Abs was decreased in 6 of 17 p53 Abs-carrying patients after chemotherapy. However, the decreasing p53 Abs titers were not correlated with patients' survival or chemotherapeutic efficacy.CONCLUSIONSThe prevalence of p53 Abs in Taiwanese lung cancer is much lower than that in Caucasians. It is unlikely that p53 Abs titer could be a monitoring indicator for the chemotherapeutic efficacy or a prognosis indicator of lung cancer.
Correlation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been investigated. Our present study aimed at evaluating putative possibility of using p53 Abs levels as a model system to monitor effect of chemotherapy and prognosis prediction of lung cancer. The prevalence of p53 Abs in lung cancer patients and temporal alteration of p53 Abs titers in lung cancer patients carrying p53 Abs were investigated by using ELISA and Western blot analysis. p53 Abs was detected in 17 of 277 (6.14%) lung cancer patients, the positivity of p53 Abs in patients with small cell lung carcinoma and non-small cell lung carcinoma was 4.88% and 6.36%, respectively. No significant association between p53 Abs and patients' clinical manifestations was found. Titer of p53 Abs was decreased in 6 of 17 p53 Abs-carrying patients after chemotherapy. However, the decreasing p53 Abs titers were not correlated with patients' survival or chemotherapeutic efficacy. The prevalence of p53 Abs in Taiwanese lung cancer is much lower than that in Caucasians. It is unlikely that p53 Abs titer could be a monitoring indicator for the chemotherapeutic efficacy or a prognosis indicator of lung cancer.
Author Chiou, Hui-Ling
Chang, Gee-Chen
Chang, Yih-Hsin
Shiau, Ming-Yuh
Lee, Yao-Ling
Shih, Chuen-Ming
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Issue 1
Keywords ACC
SCLC
PR
NSCLC
Lung cancer
C/T
p53 Abs
LCC
SCC
Chemotherapy
PD
R/T
Anti-p53 autoantibodies
Ca
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Snippet Correlation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been investigated....
BACKGROUNDCorrelation between p53 autoantibodies (p53 Abs) titers and the efficacy of Taiwanese lung cancer patients undergoing chemotherapy has never been...
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StartPage 87
SubjectTerms Adult
Aged
Aged, 80 and over
Anti-p53 autoantibodies
Antineoplastic Agents - therapeutic use
Autoantibodies - analysis
Blotting, Western
Chemotherapy
DNA, Complementary - biosynthesis
DNA, Complementary - genetics
Electrophoresis, Polyacrylamide Gel
Enzyme-Linked Immunosorbent Assay
Female
Humans
Lung cancer
Lung Neoplasms - blood
Lung Neoplasms - drug therapy
Lung Neoplasms - immunology
Male
Middle Aged
Prognosis
Taiwan
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - chemistry
Tumor Suppressor Protein p53 - immunology
Title Alteration of autoantibodies against p53 in Taiwanese lung cancer patients undergoing chemotherapy
URI https://dx.doi.org/10.1016/j.cccn.2004.06.008
https://www.ncbi.nlm.nih.gov/pubmed/15469860
https://search.proquest.com/docview/66956300
Volume 349
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