Nitazoxanide inhibits osteosarcoma cells growth and metastasis by suppressing AKT/mTOR and Wnt/β-catenin signaling pathways

• Published in: Biological chemistry Vol. 403; no. 10; pp. 929 - 943
• Main Authors: Ye, Caihong, Wei, Mengqi, Huang, Huakun, Wang, Yuping, Zhang, Lulu, Yang, Chunmei, Huang, Yanran, Luo, Jinyong
• Format: Journal Article
• Language: English
• Published: Berlin De Gruyter 27.09.2022; Walter de Gruyter GmbH
• Subjects: AKT protein; Antiparasitic agents; Apoptosis; Bone cancer; Bone tumors; Cell cycle; Cell migration; Chemotherapy; G1 phase; Metastases; Metastasis; Osteosarcoma; Osteosarcoma cells; proliferation; Signal transduction; Signaling; signaling pathways; TOR protein; Wnt protein; β-Catenin

Osteosarcoma (OS) is the most prevalent malignant bone tumor with poor prognosis. Developing new drugs for the chemotherapy of OS has been a focal point and a major obstacle of OS treatment. Nitazoxanide (NTZ), a conventional anti-parasitic agent, has got increasingly noticed because of its favorabl...