Cocrystals of a 1,2,4-thiadiazole-based potent neuroprotector with gallic acid: solubility, thermodynamic stability relationships and formation pathways

• Published in: Physical chemistry chemical physics : PCCP Vol. 20; no. 21; pp. 14469 - 14481
• Main Authors: Surov, Artem O., Churakov, Andrei V., Proshin, Alexey N., Dai, Xia-Lin, Lu, Tongbu, Perlovich, German L.
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 2018
• Subjects: Acetonitrile; Acids; Cocrystallization; Dehydration; Gallic acid; Molecular chains; Stability; Stoichiometry; Thiadiazoles; Water chemistry

Three distinct solid forms, namely anhydrous cocrystals with 2 : 1 and 1 : 1 drug/acid ratios ([ TDZ  :  GA ] (2 : 1), [ TDZ  :  GA ] (1 : 1)), and a hydrated one having 1 : 1 : 1 drug/acid/water stoichiometry ([ TDZ  :  GA  :  H2O ] (1 : 1 : 1)), have been formed by cocrystallization of the biologi...