DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma

• Published in: Annals of surgery
• Main Authors: Kim, Hyo In, Park, Jinbong, Gallo, David, Shankar, Sidharth, Konecna, Barbora, Han, Yohan, Banner-Goodspeed, Valerie, Capers, Krystal R, Ko, Seong-Gyu, Otterbein, Leo E, Itagaki, Kiyoshi, Hauser, Carl J
• Format: Journal Article
• Language: English
• Published: United States 01.12.2023

Surgery injures tissue and predisposes to local and systemic infections. We studied injury-induced immune dysfunction seeking novel means to reverse such predisposition. Injury mobilizes primitive 'DANGER signals' (DAMPs) activating innate immunocyte (neutrophils, PMN) signaling and functi...