MULTIPLE-OUTCOME META-ANALYSIS OF CLINICAL TRIALS

• Published in: Statistics in medicine Vol. 15; no. 5; pp. 537 - 557
• Main Authors: BERKEY, C. S., ANDERSON, J. J., HOAGLIN, D. C.
• Format: Journal Article
• Language: English
• Published: Chichester Wiley Subscription Services, Inc., A Wiley Company 15.03.1996; Wiley
• Subjects: Antirheumatic Agents - therapeutic use; Arthritis, Rheumatoid - drug therapy; Auranofin - therapeutic use; Biological and medical sciences; Computerized, statistical medical data processing and models in biomedicine; Gold - therapeutic use; Humans; Least-Squares Analysis; Medical sciences; Medical statistics; Meta-Analysis as Topic; Randomized Controlled Trials as Topic - methods; Regression Analysis; Clinical trial; Regression model; Statistical model; Metaanalysis

When several clinical trials report multiple outcomes, meta‐analyses ordinarily analyse each outcome separately. Instead, by applying generalized‐least‐squares (GLS) regression, Raudenbush et al. showed how to analyse the multiple outcomes jointly in a single model. A variant of their GLS approach,...