The Effect of Intravenous Lidocaine, Ketamine, and Lidocaine-Ketamine Combination in Colorectal Cancer Surgery: A Randomized Controlled Trial

• Published in: Anesthesia and analgesia Vol. 140; no. 1; p. 67
• Main Authors: Ostović, Helena, Šimac, Brankica, Pražetina, Marko, Bradić, Nikola, Peršec, Jasminka
• Format: Journal Article
• Language: English
• Published: United States 01.01.2025
• Subjects: Aged; Analgesics - administration & dosage; Anesthetics, Local - administration & dosage; Colectomy - adverse effects; Colorectal Neoplasms - surgery; Double-Blind Method; Female; Humans; Infusions, Intravenous; Ketamine - administration & dosage; Lidocaine - administration & dosage; Male; Middle Aged; Pain, Postoperative - diagnosis; Pain, Postoperative - etiology; Pain, Postoperative - prevention & control; Treatment Outcome

Colorectal resections are associated with a pronounced inflammatory response, severe postoperative pain, and postoperative ileus. The aim of this study was to evaluate the main effects of lidocaine and ketamine, and their interaction in colorectal cancer (CRC) patients after open surgery. The intera...