White Matter Perivascular Spaces on Magnetic Resonance Imaging: Marker of Cerebrovascular Amyloid Burden?

• Published in: Stroke (1970) Vol. 46; no. 6; pp. 1707 - 1709
• Main Authors: Charidimou, Andreas, Hong, Young T., Jäger, Hans R., Fox, Zoe, Aigbirhio, Franklin I., Fryer, Tim D., Menon, David K., Warburton, Elizabeth A., Werring, David J., Baron, Jean-Claude
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.06.2015
• Subjects: Adult; Amyloid beta-Peptides - metabolism; Aniline Compounds - administration & dosage; Biomarkers - metabolism; Cerebral Amyloid Angiopathy - diagnostic imaging; Cerebral Amyloid Angiopathy - metabolism; Cerebral Angiography; Female; Humans; Magnetic Resonance Angiography; Male; Middle Aged; Pilot Projects; Prospective Studies; Thiazoles - administration & dosage; White Matter - diagnostic imaging; White Matter - metabolism; cerebral amyloid angiopathy

BACKGROUND AND PURPOSE—We investigated the relationship between magnetic resonance imaging-visible centrum semiovale perivascular spaces (CSO-PVS), a biomarker of impaired interstitial fluid drainage, and positron emission tomography–based amyloid-β burden across a wide range of cerebrovascular amyl...