Quantification and Functional Studies of Neutrophilic Cells Identifies Distinct Papilloma Phenotypes

• Published in: The Laryngoscope Vol. 134; no. 7; pp. 3238 - 3244
• Main Authors: Bai, Ke, Clavijo, Paul E., Robbins, Yvette, Norberg, Scott M., Allen, Clint T.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.07.2024
• Subjects: Adult; Aged; Female; Flow Cytometry; functional assays; human papillomavirus; Humans; immunosuppression; Laryngeal Neoplasms - immunology; Laryngeal Neoplasms - pathology; laryngeal papilloma; Male; Middle Aged; neutrophilic cells; Neutrophils - immunology; Neutrophils - pathology; Papilloma - immunology; Papilloma - pathology; Papillomavirus Infections - immunology; Papillomavirus Infections - pathology; Phenotype; recurrent respiratory papillomatosis; Respiratory Tract Infections - immunology; Respiratory Tract Infections - pathology; T-Lymphocytes, Regulatory - immunology; Tumor Microenvironment - immunology; functional assays; immunosuppression; recurrent respiratory papillomatosis; neutrophilic cells; human papillomavirus; laryngeal papilloma

Objectives To characterize the distribution of immune cell subsets within laryngeal papillomas and to study the function of potentially immunosuppressive neutrophilic and regulatory T cells (Tregs). Methods Fresh clinical papilloma specimens were collected at the time of surgery and studied with mul...