Extracellular Vesicle Surface Markers as a Diagnostic Tool in Transient Ischemic Attacks

• Published in: Stroke (1970) Vol. 52; no. 10; pp. 3335 - 3347
• Main Authors: Burrello, Jacopo, Bianco, Giovanni, Burrello, Alessio, Manno, Concetta, Maulucci, Francesco, Pileggi, Marco, Nannoni, Stefania, Michel, Patrik, Bolis, Sara, Melli, Giorgia, Vassalli, Giuseppe, Albers, Gregory W., Cianfoni, Alessandro, Barile, Lucio, Cereda, Carlo W.
• Format: Journal Article
• Language: English
• Published: United States Lippincott Williams & Wilkins 01.10.2021
• Subjects: Aged; Aged, 80 and over; Antigens, Surface - analysis; Biomarkers; Brain Ischemia - complications; Brain Ischemia - pathology; Cohort Studies; Extracellular Vesicles - pathology; Female; Flow Cytometry; Humans; Ischemic Attack, Transient - diagnosis; Ischemic Attack, Transient - pathology; Male; Middle Aged; Nanoparticles - analysis; Prospective Studies; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; magnetic resonance imaging; flow cytometry; transient ischemic attack; extracellular vesicles; biomarker; fluorescence

Extracellular vesicles (EVs) are promising biomarkers for cerebral ischemic diseases, but not systematically tested in patients with transient ischemic attacks (TIAs). We aimed at (1) investigating the profile of EV-surface antigens in patients with symptoms suspicious for TIA; (2) developing and va...