Can proinflammatory cytokine gene expression explain multifidus muscle fiber changes after an intervertebral disc lesion?

• Published in: Spine (Philadelphia, Pa. 1976) Vol. 39; no. 13; p. 1010
• Main Authors: Hodges, Paul W, James, Gregory, Blomster, Linda, Hall, Leanne, Schmid, Annina B, Shu, Cindy, Little, Chris, Melrose, James
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Animals; Disease Models, Animal; Gene Expression - immunology; Interleukin-1beta - genetics; Interleukin-1beta - immunology; Intervertebral Disc Degeneration - genetics; Intervertebral Disc Degeneration - immunology; Intervertebral Disc Degeneration - pathology; Lumbar Vertebrae; Male; Muscle Fibers, Skeletal - immunology; Muscle Fibers, Skeletal - pathology; Muscle Fibers, Slow-Twitch - immunology; Muscle Fibers, Slow-Twitch - pathology; Orchiectomy; Paraspinal Muscles - immunology; Paraspinal Muscles - pathology; Sheep; Tumor Necrosis Factor-alpha - genetics; Tumor Necrosis Factor-alpha - immunology

Longitudinal case-controlled animal study. To investigate the effect of an intervertebral disc (IVD) lesion on the proportion of slow, fast, and intermediate muscle fiber types in the multifidus muscle in sheep, and whether muscle fiber changes were paralleled by local gene expression of the proinfl...