Clinical features of UK Biobank subjects carrying protein-truncating variants in genes implicated in schizophrenia pathogenesis

• Published in: Psychiatric genetics Vol. 32; no. 4; p. 156
• Main Author: Curtis, David
• Format: Journal Article
• Language: English
• Published: England 01.08.2022
• Subjects: Biological Specimen Banks; Exome; Histone-Lysine N-Methyltransferase - genetics; Humans; Phenotype; Schizophrenia - epidemiology; Schizophrenia - genetics; United Kingdom; United Kingdom

The SCHEMA consortium has identified 10 genes in which protein-truncating variants (PTVs) confer a substantial risk of schizophrenia. This study aimed to determine whether carrying these PTVs was associated with neuropsychiatric impairment in the general population. Phenotype fields of exome-sequenc...