Impact of organic anion transporting polypeptide, P-glycoprotein, and breast cancer resistance protein transporters on observed tamoxifen and endoxifen concentration and adverse effects

• Published in: Pharmacogenetics and genomics Vol. 33; no. 1; p. 10
• Main Authors: Keller, Denise N, Medwid, Samantha J, Ross, Cameron D, Wigle, Theodore J, Kim, Richard B
• Format: Journal Article
• Language: English
• Published: United States 01.01.2023
• Subjects: ATP Binding Cassette Transporter, Subfamily B - genetics; ATP Binding Cassette Transporter, Subfamily B - metabolism; ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics; ATP Binding Cassette Transporter, Subfamily G, Member 2 - genetics; Breast Neoplasms - drug therapy; Breast Neoplasms - genetics; Drug-Related Side Effects and Adverse Reactions; Female; HEK293 Cells; Humans; Liver-Specific Organic Anion Transporter 1 - genetics; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Organic Anion Transporters - genetics; Tamoxifen - adverse effects

Drug transporters are important determinants of drug disposition and response. Tamoxifen is an antiestrogen for breast cancer therapy known for adverse drug reactions (ADRs). In this study, the involvement of OATP transporters in tamoxifen and endoxifen transport was studied in vitro while the impac...