Cellular senescence is a double‐edged sword in regulating aged immune responses to influenza

• Published in: Aging cell Vol. 23; no. 7; pp. e14162 - n/a
• Main Authors: Torrance, Blake L., Cadar, Andreia N., Panier, Hunter A., Martin, Dominique E., Lorenzo, Erica C., Jellison, Evan R., Bartley, Jenna M., Haynes, Laura
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.07.2024
• Subjects: Age; Aging; Blood; CD8 antigen; Cell cycle; Chronic illnesses; Chronic infection; Coronaviruses; Flow cytometry; Ganciclovir; Immune clearance; Immune system; Immunological memory; Infections; Inflammation; Influenza; Laboratory animals; Lungs; Lymphocytes; Lymphocytes T; memory; Memory cells; Older people; p16; Pathogens; Senescence; Swine flu; T cells; Viral infections; United States > US; Puerto Rico; influenza; senescence; memory; aging; p16; T cells

Clearance of senescent cells has demonstrated therapeutic potential in the context of chronic age‐related diseases. Little is known, however, how clearing senescent cells affects the ability to respond to an acute infection and form quality immunological memory. We aimed to probe the effects of clea...