Intramuscular Nanofat Injection Promotes Inflammation-Induced Gastrocnemius Regeneration in a Syngeneic Rat Sciatic Nerve Injury Model

• Published in: Plastic and reconstructive surgery (1963) Vol. 151; no. 6; p. 947e
• Main Authors: Schilling, Benjamin K, Baker, Jocelyn S, Komatsu, Chiaki, Turer, David M, Bengur, Fuat Baris, Nerone, W Vincent, Qin, Feng, Cottrill, Adam R, Kokai, Lauren E, Rubin, J Peter, Marra, Kacey G
• Format: Journal Article
• Language: English
• Published: United States 01.06.2023
• Subjects: Animals; Cytokines; Injections, Intramuscular; Interleukin-18; Nerve Regeneration - physiology; Peripheral Nerve Injuries; Rats; Rats, Inbred Lew; Sciatic Nerve - injuries; Sciatic Neuropathy; Tissue Inhibitor of Metalloproteinase-1; Vascular Endothelial Growth Factor A

Mechanical emulsification of adipose tissue to concentrate protein and stromal cell components (ie, nanofat) has gained considerable interest in clinical practice. Although the regenerative potential of nanofat has largely been used in aesthetic applications, these effects have considerable potentia...