Circ_KIAA1199 inhibits MSI1 degradation by targeting miR-34c-5p to drive the malignant cell behaviors and tumor growth of colorectal cancer

• Published in: Anti-cancer drugs Vol. 33; no. 1; p. e134
• Main Authors: Zhang, Yanbo, Yu, Hailong, Guo, Zhen
• Format: Journal Article
• Language: English
• Published: England 01.01.2022
• Subjects: Animals; Apoptosis - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Cell Proliferation - drug effects; Colorectal Neoplasms - pathology; Down-Regulation - drug effects; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; MicroRNAs - drug effects; Nerve Tissue Proteins - drug effects; RNA, Circular - pharmacology; RNA-Binding Proteins - drug effects; Tumor Burden; Xenograft Model Antitumor Assays

Circular RNAs (circRNAs) are important regulators that drive or inhibit cancer initiation and development. Here, we identified the expression and function of a circRNA, circ_KIAA1199, in colorectal cancer (CRC). The expression levels of circ_KIAA1199, microRNA-34c-5p (miR-34c-5p) and Musashi RNA-bin...