Harmonized Multisite MRI‐Based Quantification of Human Liver Fat and Stiffness: A Pilot Study

• Published in: Journal of magnetic resonance imaging Vol. 59; no. 3; pp. 1070 - 1073
• Main Authors: Carmichael, Owen T., Singh, Maninder, Bashir, Adil, Russell, Anne M., Bolding, Mark, Redden, David T., Storrs, Judd, Willoughby, William R., Howard‐Claudio, Candace, Hsia, Daniel S., Kimberly, Robert P., Gray, Meagan E., Ravussin, Eric, Denney, Thomas S.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2024; Wiley Subscription Services, Inc
• Subjects: Adult; Biopsy; Clinical trials; Confidence intervals; Effectiveness; elasticity imaging techniques; Fatty liver; Field strength; Humans; Liver; Liver - pathology; Liver diseases; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Magnetic resonance spectroscopy; Medical imaging; Non-alcoholic Fatty Liver Disease - pathology; nonalcoholic fatty liver disease; Obesity; Obesity - pathology; Pilot Projects; Proton density (concentration); Reproducibility; Reproducibility of Results; Standardization; Statistical analysis; Statistical tests; Stiffness; elasticity imaging techniques; magnetic resonance spectroscopy; magnetic resonance imaging; nonalcoholic fatty liver disease

Background Nonalcoholic fatty liver disease (NAFLD) is a leading cause of end‐stage liver disease. NAFLD diagnosis and follow‐up relies on a combination of clinical data, liver imaging, and/or liver biopsy. However, intersite imaging differences impede diagnostic consistency and reduce the repeatabi...