Loss of Histone Deacetylase 4 in Hepatocytes Increases De Novo Lipogenesis in Diet-Induced Obesity Mice

• Published in: Current developments in nutrition Vol. 4; no. Supplement_2; p. nzaa063_050
• Main Authors: Lee, Yoojin, Bae, Minkyung, Chamberlain, Dana, Pham, Tho, Kang, Hyunju, Kim, Mi-Bo, Hu, Siqi, Park, Young-Ki, Lee, Ji-Young
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Inc 01.06.2020; Oxford University Press
• Subjects: Adipocytes; Body fat; Fatty liver; Gastroenterology and Hepatology; Liver; Obesity

Evidence suggests that histone deacetylase 4 (HDAC4) is downregulated in adipose tissue of obese subjects. We determined the role of HDAC4 in the regulation of energy metabolism of metabolically active tissues, such as the liver and adipose tissue. Hepatocyte-specific (Hdac4HKO) and adipocyte-specif...