Vitamin K-dependent carboxylation regulates Ca2+ flux and adaptation to metabolic stress in β cells

• Published in: Cell reports (Cambridge) Vol. 42; no. 5; p. 112500
• Main Authors: Lacombe, Julie, Guo, Kevin, Bonneau, Jessica, Faubert, Denis, Gioanni, Florian, Vivoli, Alexis, Muir, Sarah M., Hezzaz, Soraya, Poitout, Vincent, Ferron, Mathieu
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 30.05.2023; Elsevier
• Subjects: CP: Metabolism; diabetes; ERGP; GGCX; insulin secretion; store-operated calcium entry; vitamin K; β cells; γ-carboxylation; GGCX; CP: Metabolism; ERGP; β cells; store-operated calcium entry; γ-carboxylation; insulin secretion; vitamin K; diabetes

Vitamin K is a micronutrient necessary for γ-carboxylation of glutamic acids. This post-translational modification occurs in the endoplasmic reticulum (ER) and affects secreted proteins. Recent clinical studies implicate vitamin K in the pathophysiology of diabetes, but the underlying molecular mech...