Matrix metalloproteinase-3 gene polymorphisms are associated with ischemic stroke

• Published in: Journal of interferon & cytokine research Vol. 32; no. 2; pp. 81 - 86
• Main Authors: Kim, Su Kang, Kang, Sung Wook, Kim, Dong Hwan, Yun, Dong Hwan, Chung, Joo-Ho, Ban, Ju Yeon
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.02.2012
• Subjects: Adult; Aged; Asian Continental Ancestry Group; Brain Ischemia - enzymology; Brain Ischemia - genetics; Cerebral Hemorrhage - enzymology; Cerebral Hemorrhage - genetics; Data processing; Female; Gene polymorphism; Haplotypes; Hemorrhage; Humans; Interferon; Ischemia; Male; Matrix metalloproteinase; Matrix Metalloproteinase 3 - genetics; Matrix Metalloproteinase 3 - metabolism; Middle Aged; Polymorphism, Single Nucleotide; Regression analysis; Republic of Korea; Sex Characteristics; Sex Factors; Single-nucleotide polymorphism; Stroke; Stroke - enzymology; Stroke - genetics; Stromelysin 1; Republic of Korea

Stroke is a heterogeneous disease caused by different pathogenic mechanisms. Several candidate genes for stroke have been proposed, but few have been replicated. Matrix metalloproteinases (MMPs) are expressed following stroke. We investigated the association of single nucleotide polymorphisms (SNPs)...