Kinetic barriers to α-synuclein protofilament formation and conversion into mature fibrils

• Published in: Chemical communications (Cambridge, England) Vol. 54; no. 56; pp. 7854 - 7857
• Main Authors: Brown, James W P, Meisl, Georg, Knowles, Tuomas P J, Buell, Alexander K, Dobson, Christopher M, Galvagnion, Céline
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 10.07.2018
• Subjects: Conversion; Molecular structure; Parkinson's disease; Proteins

Oligomeric and protofibrillar aggregates that are populated along the pathway of amyloid fibril formation appear generally to be more toxic than the mature fibrillar state. In particular, α-synuclein, the protein associated with Parkinson's disease, forms kinetically trapped protofibrils in the...