Induction of antitumor immunity with modified autologous cells expressing membrane-bound murine cytokines

• Published in: Journal of interferon & cytokine research Vol. 19; no. 12; pp. 1391 - 1401
• Main Authors: el-Shami, K M, Tzehoval, E, Vadai, E, Feldman, M, Eisenbach, L
• Format: Journal Article
• Language: English
• Published: United States Mary Ann Liebert, Inc 01.12.1999
• Subjects: Animals; Base Sequence; Cancer Vaccines - genetics; Cancer Vaccines - immunology; Cancer Vaccines - pharmacology; Cell Membrane - immunology; Cytokines - genetics; DNA Primers - genetics; Female; g-Interferon; Gene Expression; Granulocyte-Macrophage Colony-Stimulating Factor - genetics; Interferon-gamma - genetics; Lung Neoplasms - immunology; Lung Neoplasms - secondary; Lung Neoplasms - therapy; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Recombinant Proteins; T-Lymphocytes, Cytotoxic - immunology; Transfection; Transplantation, Autologous

Development of cytokine gene-modified autologous tumor vaccines must take into account the strictly paracrine physiology of cytokines whose expression at the tumor microenvironment is important for the successful induction of tumor-specific immunity. In this study, we investigated the efficacy of a...