A Different Perspective: How Much Innovation Is Really Needed for Monoclonal Antibody Production Using Mammalian Cell Technology?

• Published in: Advances in biochemical engineering, biotechnology Vol. 165; p. 443
• Main Authors: Kelley, Brian, Kiss, Robert, Laird, Michael
• Format: Journal Article
• Language: English
• Published: Germany 01.01.2018
• Subjects: Mabs; Innovation; Cell culture production; Monoclonal antibodies, Perfusion; CHO technology; Mammalian cell technology; Continuous processing; CHO platform

As biopharmaceutical companies have optimized cell line and production culture process development, titers of recombinant antibodies have risen steadily to 3-8 g/L for fed-batch mammalian cultures at production scales of 10 kL or larger. Most new antibody products are produced from Chinese Hamster O...