Gene Expression Profiling with DNA Microarrays: Advancing Our Understanding of Psychiatric Disorders
DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subje...
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| Published in | Neurochemical research Vol. 27; no. 10; pp. 1049 - 1063 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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United States
Springer Nature B.V
01.10.2002
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| Online Access | Get full text |
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| Abstract | DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings. |
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| AbstractList | DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings. DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings.DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric disorders. With careful analysis and interpretation of microarray data we are uncovering previously unknown, expression patterns that maybe subject-specific and pivotal in understanding the disease process. In our recent studies, analyses of the prefrontal cortex of subjects with schizophrenia and matched controls uncovered complex changes in the expression of genes related to presynaptic secretory release, GABAergic and glutamatergic transmission, metabolic pathways, myelination, as well as cAMP and phosphoinositol second messenger systems. Our goal will be to integrate this expression data within the context of the relevant anatomical, biochemical, molecular, imaging and clinical findings. |
| Author | Mirnics, Károly Pongrac, Julie Middleton, Frank A. Lewis, David A. Levitt, Pat |
| Author_xml | – sequence: 1 givenname: Julie surname: Pongrac fullname: Pongrac, Julie – sequence: 2 givenname: Frank A. surname: Middleton fullname: Middleton, Frank A. – sequence: 3 givenname: David A. surname: Lewis fullname: Lewis, David A. – sequence: 4 givenname: Pat surname: Levitt fullname: Levitt, Pat – sequence: 5 givenname: Károly surname: Mirnics fullname: Mirnics, Károly |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/12462404$$D View this record in MEDLINE/PubMed |
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| Snippet | DNA microarray transcriptome profiling of the postmortem brain opens novel horizons in understanding molecular changes associated with complex psychiatric... |
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| SubjectTerms | Brain - physiopathology Gene Expression Profiling - methods Humans Mental Disorders - genetics Mental Disorders - physiopathology Oligonucleotide Array Sequence Analysis Schizophrenia - genetics Schizophrenia - physiopathology Synapses - physiology |
| Title | Gene Expression Profiling with DNA Microarrays: Advancing Our Understanding of Psychiatric Disorders |
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