Spt5 interacts genetically with Myc and is limiting for brain tumor growth in Drosophila

• Published in: Life science alliance Vol. 7; no. 1; p. e202302130
• Main Authors: Hofstetter, Julia, Ogunleye, Ayoola, Kutschke, André, Buchholz, Lisa Marie, Wolf, Elmar, Raabe, Thomas, Gallant, Peter
• Format: Journal Article
• Language: English
• Published: United States Life Science Alliance LLC 2024
• Subjects: Animals; Brain - metabolism; Brain Neoplasms - genetics; Drosophila - genetics; Drosophila - metabolism; Humans; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Transcriptional Elongation Factors - metabolism

The transcription factor SPT5 physically interacts with MYC oncoproteins and is essential for efficient transcriptional activation of MYC targets in cultured cells. Here, we use to address the relevance of this interaction in a living organism. Spt5 displays moderate synergy with Myc in fast prolife...