Metastatic papillary thyroid carcinoma with no primary tumor in the thyroid gland: a case report and review of literature
Metastatic papillary thyroid carcinoma in the lymph nodes with no primary tumor in the thyroid gland is rarely reported and is easily missed. We report the case of a 27-year-old female who presented with a tiny nodule in her left thyroid gland, which was detected during a routine ultrasonographic ex...
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Published in | Translational cancer research Vol. 11; no. 1; pp. 299 - 305 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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China
AME Publishing Company
01.01.2022
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Abstract | Metastatic papillary thyroid carcinoma in the lymph nodes with no primary tumor in the thyroid gland is rarely reported and is easily missed. We report the case of a 27-year-old female who presented with a tiny nodule in her left thyroid gland, which was detected during a routine ultrasonographic examination. She did not present with fever, weight loss, or night sweats, and no palpable mass was found in the physical examination. The preoperative blood routine, thyroid function, and thyroglobulin test results were normal. Needle aspiration cytology of the thyroid and lymph nodes was recommended. However, the patient was anxious and refused to have a fine-needle aspiration biopsy (FNAB), requesting surgical excision instead. The patient underwent a left thyroid lobectomy and ipsilateral central lymph node dissection under general anesthesia. Metastasis of papillary thyroid carcinoma was found in the central lymph nodes although there was no primary tumor in the left thyroid gland. We reviewed the literature and found the possible hypotheses to explain this phenomenon included the lack of a pathologic biopsy, tumor regression, and ectopic thyroid carcinoma. After 2 years of follow-up, no recurrence or metastasis of the tumor was found in this patient. In conclusion, we believe attention should be paid to occult thyroid cancer with papillary carcinoma in the lymph nodes so as to avoid missed diagnoses and delayed treatment. |
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AbstractList | Metastatic papillary thyroid carcinoma in the lymph nodes with no primary tumor in the thyroid gland is rarely reported and is easily missed. We report the case of a 27-year-old female who presented with a tiny nodule in her left thyroid gland, which was detected during a routine ultrasonographic examination. She did not present with fever, weight loss, or night sweats, and no palpable mass was found in the physical examination. The preoperative blood routine, thyroid function, and thyroglobulin test results were normal. Needle aspiration cytology of the thyroid and lymph nodes was recommended. However, the patient was anxious and refused to have a fine-needle aspiration biopsy (FNAB), requesting surgical excision instead. The patient underwent a left thyroid lobectomy and ipsilateral central lymph node dissection under general anesthesia. Metastasis of papillary thyroid carcinoma was found in the central lymph nodes although there was no primary tumor in the left thyroid gland. We reviewed the literature and found the possible hypotheses to explain this phenomenon included the lack of a pathologic biopsy, tumor regression, and ectopic thyroid carcinoma. After 2 years of follow-up, no recurrence or metastasis of the tumor was found in this patient. In conclusion, we believe attention should be paid to occult thyroid cancer with papillary carcinoma in the lymph nodes so as to avoid missed diagnoses and delayed treatment. |
Author | Gao, Han Xiao, Qian Zhou, Jing Li, Daxue Li, Jiazhen |
Author_xml | – sequence: 1 givenname: Daxue surname: Li fullname: Li, Daxue organization: Department of Breast and Thyroid Surgery, Chongqing Health Center for Women and Children, Chongqing, China – sequence: 2 givenname: Jiazhen surname: Li fullname: Li, Jiazhen organization: Department of Medical Ultrasonics, General Hospital of Chonggang, Chongqing, China – sequence: 3 givenname: Jing surname: Zhou fullname: Zhou, Jing organization: Department of Breast and Thyroid Surgery, Chongqing Health Center for Women and Children, Chongqing, China – sequence: 4 givenname: Qian surname: Xiao fullname: Xiao, Qian organization: Department of Breast and Thyroid Surgery, Chongqing Health Center for Women and Children, Chongqing, China – sequence: 5 givenname: Han surname: Gao fullname: Gao, Han organization: Department of Breast and Thyroid Surgery, Chongqing Health Center for Women and Children, Chongqing, China |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35261906$$D View this record in MEDLINE/PubMed |
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Copyright | 2022 Translational Cancer Research. All rights reserved. 2022 Translational Cancer Research. All rights reserved. 2022 Translational Cancer Research. |
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Keywords | case report occult thyroid carcinoma (OTC) Papillary thyroid carcinoma lymph node metastasis |
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License | 2022 Translational Cancer Research. All rights reserved. Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
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Notes | ORCID: Daxue Li, 0000-0002-2701-1370; Han Gao, 0000-0001-8578-2037. |
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Title | Metastatic papillary thyroid carcinoma with no primary tumor in the thyroid gland: a case report and review of literature |
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