Noninvasive analysis of volatile biomarkers in human emanations for health and early disease diagnosis

Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the components of breath exhalations and skin emissions may be diagnostic biomarkers for various diseases and metabolic disorders. Since hundreds of en...

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Published inBioanalysis Vol. 5; no. 11; pp. 1443 - 1459
Main Authors Kataoka, Hiroyuki, Saito, Keita, Kato, Hisato, Masuda, Kazufumi
Format Journal Article
LanguageEnglish
Published England 01.06.2013
Subjects
Animals
Biomarkers - analysis
Breath Tests - instrumentation
Breath Tests - methods
Chromatography, Gas - instrumentation
Chromatography, Gas - methods
Early Diagnosis
Equipment Design
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Odorants - analysis
Olfactometry - instrumentation
Olfactometry - methods
Solid Phase Microextraction - instrumentation
Solid Phase Microextraction - methods
Volatile Organic Compounds - analysis
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Abstract Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the components of breath exhalations and skin emissions may be diagnostic biomarkers for various diseases and metabolic disorders. Since hundreds of endogenous and exogenous volatile organic compounds (VOCs) are released from the human body, analysis of these VOCs may be a noninvasive, painless, and easy diagnostic tool. Sampling and preconcentration by sorbent tubes/traps and solid-phase microextraction, in combination with GC or GC-MS, are usually used to analyze VOCs. In addition, GC-MS-olfactometry is useful for simultaneous analysis of odorants and odor quality. Direct MS techniques are also useful for the online real-time detection of VOCs. This review focuses on recent developments in sampling and analysis of volatile biomarkers in human odors and/or emanations, and discusses future use of VOC analysis.
AbstractList Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the components of breath exhalations and skin emissions may be diagnostic biomarkers for various diseases and metabolic disorders. Since hundreds of endogenous and exogenous volatile organic compounds (VOCs) are released from the human body, analysis of these VOCs may be a noninvasive, painless, and easy diagnostic tool. Sampling and preconcentration by sorbent tubes/traps and solid-phase microextraction, in combination with GC or GC-MS, are usually used to analyze VOCs. In addition, GC-MS-olfactometry is useful for simultaneous analysis of odorants and odor quality. Direct MS techniques are also useful for the online real-time detection of VOCs. This review focuses on recent developments in sampling and analysis of volatile biomarkers in human odors and/or emanations, and discusses future use of VOC analysis.
Author Saito, Keita
Kato, Hisato
Kataoka, Hiroyuki
Masuda, Kazufumi
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Snippet Early disease diagnosis is crucial for human healthcare and successful therapy. Since any changes in homeostatic balance can alter human emanations, the...
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StartPage 1443
SubjectTerms Animals
Biomarkers - analysis
Breath Tests - instrumentation
Breath Tests - methods
Chromatography, Gas - instrumentation
Chromatography, Gas - methods
Early Diagnosis
Equipment Design
Humans
Mass Spectrometry - instrumentation
Mass Spectrometry - methods
Odorants - analysis
Olfactometry - instrumentation
Olfactometry - methods
Solid Phase Microextraction - instrumentation
Solid Phase Microextraction - methods
Volatile Organic Compounds - analysis
Title Noninvasive analysis of volatile biomarkers in human emanations for health and early disease diagnosis
URI https://www.ncbi.nlm.nih.gov/pubmed/23742311
Volume 5
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