Probing cytochrome P450 bioactivation and fluorescent properties with morpholinyl-tethered anthraquinones - Errington, Rachel J.; Sadiq, Maria; Cosentino, Laura; Wiltshire, Marie; Sadiq, Omair; Sini, Marcella; Lizano, Enric; Pujol, Maria D.; Morais, Goreti R.; Pors, Klaus (Bioorganic & medicinal chemistry letters, 2018)
Keywords: Anthraquinone; Anthraquinones - chemical synthesis; Anthraquinones - chemistry; Anthraquinones - metabolism; Anthraquinones - toxicity; Cancer; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; CYP1A2; Cytochrome P-450 Enzyme System - metabolism; Cytochrome P450; DRAQ5; Fluorescence; Fluorescent Dyes - chemical synthesis; Fluorescent Dyes - chemistry; Fluorescent Dyes - metabolism; Fluorescent Dyes - toxicity; Fluorophore; Humans; Hydroxylation; Life Sciences & Biomedicine; MMDX; Morpholines - chemical synthesis; Morpholines - chemistry; Morpholines - metabolism; Morpholines - toxicity; Nemorubicin; Pharmacology & Pharmacy; Physical Sciences; Science & Technology; MMDX; Anthraquinone; DRAQ5; Nemorubicin; Fluorophore; Cytochrome P450; CYP1A2; Cancer; RESISTANT OVARIAN-CANCER; CELLS; ACTIVATION; AZINOMYCIN ANALOG; TUMOR; ANTITUMOR-ACTIVITY; ALCHEMIX; FCE-23762; BLADDER