Single-nucleotide polymorphisms in the TSPYL-4 and NT5DC1 genes are associated with susceptibility to chronic obstructive pulmonary disease

• Published in: Molecular medicine reports Vol. 6; no. 3; pp. 631 - 638
• Main Authors: GUO, YI, GONG, YI, SHI, GUOCHAO, YANG, KUN, PAN, CHUNMING, LI, MIN, LI, QINGYUN, CHENG, QIJIAN, DAI, RANRAN, FAN, LIANG, WAN, HUANYING
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.09.2012; Spandidos Publications UK Ltd
• Subjects: 5'-Nucleotidase - genetics; 5'-Nucleotidase - metabolism; 5′-nucleotidase domain containing 1; Adult; Aged; Alleles; Chronic obstructive pulmonary disease; Deoxyribonucleic acid; DNA; Environmental factors; Gene Frequency; Genes; Genetic Predisposition to Disease; genome-wide association studies; Genome-Wide Association Study; Genomes; Genotype; Genotyping; Haplotypes; Hospitals; Humans; Linkage Disequilibrium; Lung diseases; Male; Middle Aged; Nucleotidase; Obstructive lung disease; Pathogenesis; Polymorphism; Polymorphism, Single Nucleotide; Population; Pulmonary Disease, Chronic Obstructive - genetics; Quality control; Respiratory function; Seminal Plasma Proteins - genetics; Seminal Plasma Proteins - metabolism; Single-nucleotide polymorphism; Smoking; Software; Studies; testis-specific protein Y-encoded-like 4; Tuberculosis; China

The risk of developing chronic obstructive pulmonary disease (COPD) is partially determined by genetic and environmental factors. Many published candidate gene studies show conflicting results due to ethnic differences and sample sizes. The number of these studies carried out in Chinese populations...